Codiazine - General Information
One of the short-acting sulfonamides used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Pharmacology of Codiazine
Codiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
Additional information about Codiazine
Codiazine Indication: For the treatment of rheumatic fever and meningococcal meningitis
Mechanism Of Action: Codiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sulfadiazine
Synonyms: Sulfadiazin; Sulfadiazene; Sulfanilamidopyrimidine; Sulfapirimidin; Sulfapyrimidine; Sulfapyrimidin; Sulphadiazine; SDA
Drug Category: Antiprotozoals; Anti-Infectives
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Oral LD50 in mouse is 1500 mg/kg.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Codiazine: Not Available
Chemical IUPAC Name: 4-amino-N-pyrimidin-2-ylbenzenesulfonamide
Chemical Formula: C10H10N4O2S
Sulfadiazine on Wikipedia: https://en.wikipedia.org/wiki/Sulfadiazine
Organisms Affected: Enteric bacteria and other eubacteria