Contalyl - General Information

Contalyl (or methixene) is a anticholinergic used as an anti-parkinson drug. [Wikipedia]


Pharmacology of Contalyl

Contalyl is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Contalyl has been discontinued.


Additional information about Contalyl

Contalyl Indication: Used for the symptomatic treatment of parkinsonism.
Mechanism Of Action: Parkinsonism is thought to result from an imbalance between the excitatory (cholinergic) and inhibitory (dopaminergic) systems in the corpus striatum. The mechanism of action of centrally active anticholinergic drugs such as metixene is considered to relate to competitive antagonism of acetylcholine at cholinergic receptors in the corpus striatum, which then restores the balance.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Metixene
Synonyms: Methixen [German]; Methixene; Methixene hydrochloride; Metisene [DCIT]; Metixene hydrochloride; Metixeno [INN-Spanish]; Metixenum [INN-Latin]
Drug Category: Antiparkinson Agents; Muscarinic Antagonists
Drug Type: Small Molecule; Approved

Other Brand Names containing Metixene: Atosil; Contalyl; Methixart; Tremaril; Tremaril hydrochloride; Tremonil; Trest;
Absorption: Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Toxicity (Overdose): Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Protein Binding: Not Available
Biotransformation: Hepatic. Metabolism occurs via sulfoxydation and N-demethylation.
Half Life: Not Available
Dosage Forms of Contalyl: Not Available
Chemical IUPAC Name: 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
Chemical Formula: C20H23NS
Metixene on Wikipedia:
Organisms Affected: Humans and other mammals