Cyclaine - General Information
Cyclaine hydrochloride, also called cyclaine (Merck) or osmocaine, is a short-acting local anesthetic. It acts by inhibiting sodium channel conduction. Overdose can lead to headache, tinnitus, numbness and tingling around the mouth and tongue, convulsions, inability to breathe, and decreased heart function.
Pharmacology of Cyclaine
Cyclaine is a local ester-class anesthetic. Local anesthetics produce a transient block of nerve conduction by interfering with sodium channels. This effect of the anesthetic interferes with the development of an action potential across the nerve.
Additional information about Cyclaine
Cyclaine Indication: Used as a local anesthetic for surface application, infiltration or nerve block
Mechanism Of Action: Hexyl caine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Hexylcaine
Synonyms: Not Available
Drug Category: Anesthetics; Local Anesthetics
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Symptoms of anesthetic overdose include headache, tinnitus, circumoral and tongue paresthesias, restlessness, talkativeness, facial twitching, convulsions, respiratory arrest, and cardiac depression
Protein Binding: Not Available
Biotransformation: Hydrolyzed by plasma esterases to benzoic acid and other derivatives
Half Life: <10 minutes
Dosage Forms of Cyclaine: Not Available
Chemical IUPAC Name: 1-(cyclohexylamino)propan-2-yl benzoate
Chemical Formula: C16H23NO2
Hexylcaine on Wikipedia: https://en.wikipedia.org/wiki/Hexylcaine
Organisms Affected: Humans and other mammals