Denatured Alcohol Sd-1 - General Information
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in alcoholic beverages. [PubChem]
Pharmacology of Denatured Alcohol Sd-1
Alcohol produces injury to cells by dehydration and precipitation of the cytoplasm or protoplasm. This accounts for its bacteriocidal and antifungal action. When alcohol is injected in close proximity to nerve tissues, it produces neuritis and nerve degeneration (neurolysis). Ninety to 98% of ethanol that enters the body is completely oxidized. Denatured Alcohol Sd-1 is also used as a cosolvent to dissolve many insoluble drugs and to serve as a mild sedative in some medicinal formulations.
Denatured Alcohol Sd-1 for patients
Denatured Alcohol Sd-1 Interactions
No information provided.
Denatured Alcohol Sd-1 Contraindications
Subarachnoid injection of dehydrated alcohol is contraindicated in patients receiving anticoagulants because of the danger of bleeding.
Additional information about Denatured Alcohol Sd-1
Denatured Alcohol Sd-1 Indication: For therapeutic neurolysis of nerves or ganglia for the relief of intractable chronic pain in such conditions as inoperable cancer and trigeminal neuralgia (tic douloureux), in patients for whom neurosurgical procedures are contraindicated.
Mechanism Of Action: The sedative effects of ethanol are mediated through binding to GABA receptors and glycine receptors (alpha 1 and alpha 2 subunits). In its role as an anti-infective, ethanol acts as an osmolyte or dehydrating agent that disrupts the osmotic balance across cell membranes.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Ethanol
Synonyms: Absolute Alcohol; Absolute Ethanol; Alcohol; Alcohol Anhydrous; Alcohol, Dehydrated; Alcohol, Diluted; Alcool Ethylique; Alcool Etilico; Alkohol; Alkoholu Etylowego; Aminoethanol; Beta-Aminoethanol; Beta-Aminoethyl Alcohol; Beta-Ethanolamine; Beta-Hydroxyethylamine; Caswell No. 426; Dehydrated Ethanol; Denatured Alcohol; Denatured Ethanol; ETA; Etanolo; Ethanol 200 Proof; Ethanol Anhydrous; Ethanol Extra Pure; Ethyl Alcohol; Ethyl Alcohol Anhydrous; Ethyl Alcohol, Anhydrous; Ethyl Alcohol, Denatured; Ethyl Hydrate; Ethyl Hydroxide; Ethylolamine; Ethylol; Methylcarbinol; USAF EK-1597; HSDB 531
Drug Category: Solvents; Anti-Infective Agents, Local; Central Nervous System Depressants; Disinfectants
Drug Type: Small Molecule; Approved
Absorption: Rapidly absorbed.
Toxicity (Overdose): Oral, rat LD50: 5628 mg/kg. Symptoms and effects of overdose include nausea, vomiting, CNS depression, acute respiratory failure or death and with chronic use, severe health problems, such as liver and brain damage.
Protein Binding: Not Available
Biotransformation: Hepatic. Metabolized by cytochrome P450 enzyme CYP2E1.
Half Life: Not Available
Dosage Forms of Denatured Alcohol Sd-1: Liquid Topical
Solution / drops Oral
Chemical IUPAC Name: ethanol
Chemical Formula: C2H6O
Ethanol on Wikipedia: https://en.wikipedia.org/wiki/Ethanol
Organisms Affected: Humans and other mammals