Deuslon-A - General Information
A hydroxylated metabolite of estradiol or estrone that has a hydroxyl group at C3-beta, 16-alpha, and 17-beta position. Deuslon-A is a major urinary estrogen. During pregnancy, large amount of estriol is produced by the placenta. Isomers with inversion of the hydroxyl group or groups are called epiestriol.
Pharmacology of Deuslon-A
Deuslon-A (also oestriol) is one of the three main estrogens produced by the human body. It is only produced in significant amounts during pregnancy as it is made by the placenta. In pregnant women with multiple sclerosis (MS), estriol reduces the disease's symptoms noticeably, according to researchers at UCLA's Geffen Medical School.
Additional information about Deuslon-A
Deuslon-A Indication: Used as a test to determine the general health of an unborn fetus.
Mechanism Of Action: Deuslon-A levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of "unconjugated estriol" are abnormally low in a pregnant woman, this may indicate a problem with the development of the child.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Estriol
Synonyms: Oestriol; (16alpha,17beta)-Oestra-1,3,5(10)-triene-3,16,17-triol; (16alpha,17beta)-estra-1,3,5(10)-triene-3,16,17-triol; 1,3,5(10)-Estratriene-3,16alpha,17beta-triol; 1,3,5-Estratriene-3beta,16alpha,17beta-triol; 1,3,5-Oestratriene-3beta,16alpha,17beta-triol; 16-alpha,17-beta-Estriol; 16-alpha,17-beta-Oestriol; 16-alpha-Hydroxyestradiol; 16-alpha-Hydroxyoestradiol; 16alpha,17beta-Estriol; 16alpha,17beta-Oestriol; 16alpha-Hydroxy-17beta-estradiol; 16alpha-Hydroxyoestradiol; 16alpha-hydroxyestradiol; 3,16-alpha,17-beta-Estriol; 3,16-alpha,17-beta-Oestriol; 3,16-alpha,17-beta-Trihydroxy-delta-1,3,5-estratriene; 3,16-alpha,17-beta-Trihydroxy-delta-1,3,5-oestratriene; 3,16-alpha,17-beta-Trihydroxyestra-1,3,5(10)-triene; 3,16-alpha,17-beta-Trihydroxyoestra-1,3,5(10)-triene; 3,16alpha,17beta-Estriol; 3,16alpha,17beta-Trihydroxy-1,3,5(10)-estratriene; 3,16alpha,17beta-Trihydroxy-delta-1,3,5-oestratriene; 3,16alpha,17beta-trihydroxy-Delta(1,3,5)-estratriene; ESL; Estra-1,3,5(10)-trien-3,16alpha,17beta-triol; Estra-1,3,5(10)-triene-3,16,17-triol; Estratriol; Estriolo [italian]; Oestra-1,3,5(10)-triene-3,16alpha,17beta-triol; Oestriolum; Ovestrion; Tridestrin; 1,3,5(10)-Estratriene-3,16,17-Triol
Drug Category: Estrogens
Drug Type: Small Molecule; Approved
Other Brand Names containing Estriol: Deuslon-A; Estriel;
Absorption: Not Available
Toxicity (Overdose): ORAL (LD50): Acute: >2000 mg/kg [Rat].
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Deuslon-A: Not Available
Chemical IUPAC Name: (8R,9S,13S,14S,16R,17R)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,16,17-triol
Chemical Formula: C18H24O3
Estriol on Wikipedia: https://en.wikipedia.org/wiki/Estriol
Organisms Affected: Humans and other mammals