Diat - General Information
A commonly used x-ray contrast medium. As diatrizoate meglumine and as Diat sodium, it is used for gastrointestinal studies, angiography, and urography. [PubChem]
Pharmacology of Diat
Diat is the most commonly used water-soluble, iodinated, radiopaque x-ray contrast medium. Radiopaque agents are drugs used to help diagnose certain medical problems. They contain iodine, which blocks x-rays. Depending on how the radiopaque agent is given, it localizes or builds up in certain areas of the body. The resulting high level of iodine allows the x-rays to make a "picture" of the area. The areas of the body in which the radiopaque agent localizes will appear white on the x-ray film. This creates the needed distinction, or contrast, between one organ and other tissues. The contrast will help the doctor see any special conditions that may exist in that organ or part of the body.
Diat for patients
May interact with thyroid medication (e.g., levothyroxine), iodine-containing products, antacids, H2-antagonists (e.g., famotidine, ranitidine), and proton pump inhibitors (e.g., lansoprazole, omeprazole). This product can affect the results of certain lab tests.
Additional information about Diat
Diat Indication: Used, alone or in combination, for a wide variety of diagnostic imaging methods, including angiography, urography, cholangiography, computed tomography, hysterosalpingography, and retrograde pyelography.
Mechanism Of Action: Diat is an iodine-containing X-ray contrast agent. Iodated contrast agents were among the first contrast agents developed. Iodine is known to be particular electron-dense and to effectively scatter or stop X-rays. A good contrast agent requires a high density of electron-dense atoms. Therefore, the more iodine, the more "dense" the x-ray effect. Iodine based contrast media are water soluble and harmless to the body. These contrast agents are sold as clear colorless water solutions, the concentration is usually expressed as mg I/ml. Modern iodinated contrast agents can be used almost anywhere in the body. Most often they are used intravenously, but for various purposes they can also be used intraarterially, intrathecally (the spine) and intraabdominally - just about any body cavity or potential space.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Diatrizoate
Synonyms: Amidotrizoic Acid; Amidotrizoate; Diatriazoate; Diatrizoate sodium; Diatrizoate sodium salt; Diatrizoic acid; Diatrizoic acid sodium salt; Meglumine diatrizoate; Methalamic acid; Sodium amidotrizoate; Sodium diatrizoate; Urografin acid; Urogranoic acid
Drug Category: Contrast Media
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Diat: Solution Intravenous
Chemical IUPAC Name: 3,5-diacetamido-2,4,6-triiodobenzoic acid
Chemical Formula: C11H9I3N2O4
Diatrizoate on Wikipedia: https://en.wikipedia.org/wiki/Diatrizoate
Organisms Affected: Humans and other mammals