Dibucain - General Information
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
Pharmacology of Dibucain
Dibucain is an amide-type local anesthetic, similar to lidocaine.
Additional information about Dibucain
Dibucain Indication: For production of local or regional anesthesia by infiltration techniques such as percutaneous injection and intravenous regional anesthesia by peripheral nerve block techniques such as brachial plexus and intercostal and by central neural techniques such as lumbar and caudal epidural blocks.
Mechanism Of Action: Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
Drug Interactions: Methotrexate The NSAID increases the effect and toxicity of methotrexate
Lithium The NSAID increases serum levels of lithium
Acenocoumarol The NSAID increases the anticoagulant effect
Food Interactions: Not Available
Generic Name: Dibucaine
Synonyms: Not Available
Drug Category: Anesthetics, Local
Drug Type: Small Molecule; Approved
Absorption: In general, ionized forms (salts) of local anesthetics are not readily absorbed through intact skin. However, both nonionized (bases) and ionized forms of local anesthetics are readily absorbed through traumatized or abraded skin into the systemic circulation.
Toxicity (Overdose): Subcutaneous LD50 in rat is 27 mg/kg. Symptoms of overdose include convulsions, hypoxia, acidosis, bradycardia, arrhythmias and cardiac arrest.
Protein Binding: Not Available
Biotransformation: Primarily hepatic.
Half Life: Not Available
Dosage Forms of Dibucain: Ointment Rectal
Chemical IUPAC Name: 2-butoxy-N-(2-diethylaminoethyl)quinoline-4-carboxamide
Chemical Formula: C20H29N3O2
Dibucaine on Wikipedia: https://en.wikipedia.org/wiki/Dibucaine
Organisms Affected: Humans and other mammals