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Dicumaol R

Dicumaol R - General Information

An oral anticoagulant that interferes with the metabolism of vitamin K. It is also used in biochemical experiments as an inhibitor of reductases. [PubChem]

 

Pharmacology of Dicumaol R

Dicumaol R is an coumarin-like compound found in sweet clover. It is used as an oral anticoagulant and acts by inhibiting the hepatic synthesis of vitamin K-dependent coagulation factors (prothrombin and factors VII, IX, and X). It is also used in biochemical experiments as an inhibitor of reductases.

 

Additional information about Dicumaol R

Dicumaol R Indication: For decreasing blood clotting
Mechanism Of Action: Dicumaol R inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decresed prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dicumarol
Synonyms: Dicoumarol; Bis-Hydroxycoumarin; BHC; Bishydroxycoumarin; Dicoumarin
Drug Category: Uncoupling Agents; Anticoagulants; Enzyme Inhibitors
Drug Type: Small Molecule; Approved

Other Brand Names containing Dicumarol: Acadyl; Acavyl; Antitrombosin; Baracoumin; Cuma; Cumid; Dicoumal; Dicuman; Dicumaol R; Dicumarine; Dicumol; Dikumarol; Dufalone; Kumoran; Melitoxin; Temparin; Trombosan;
Absorption: Not Available
Toxicity (Overdose): LD50=233 mg/kg (orally in mice); LD50=250 mg/kg (orally in rats)
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Dicumaol R: Tablet Oral
Chemical IUPAC Name: 2-hydroxy-3-[(2-hydroxy-4-oxochromen-3-yl)methyl]chromen-4-one
Chemical Formula: C19H12O6
Dicumarol on Wikipedia: https://en.wikipedia.org/wiki/Dicumarol
Organisms Affected: Humans and other mammals