Dilosyn - General Information
Dilosyn is a phenothiazine compound with antihistaminic activity. It is used in the treatment of various dermatoses to relieve pruritus.
Pharmacology of Dilosyn
In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Dilosyn is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.
Dilosyn for patients
Contraindicated in the following: blood disease, heart or blood vessel disease (may cause more serious conditions to develop), enlarged prostate, urinary tract blockage or difficult urination (phenothiazine-derivative antihistamines may cause urinary problems to become worse), epilepsy (phenothiazine-derivative antihistamines, especially promethazine given by injection, may increase the chance of seizures), glaucoma (may cause a slight increase in inner eye pressure that may worsen the condition, jaundice (phenothiazine-derivative antihistamines may make the condition worse), liver disease (phenothiazine-derivative antihistamines may build up in the body, which may increase the chance of side effects such as muscle spasms), Reye's syndrome (phenothiazine-derivative antihistamines, especially promethazine given by injection, may increase the chance of uncontrolled movements).
Additional information about Dilosyn
Dilosyn Indication: Used for the symptomatic relief of hypersensitivity reactions and particularly for the control of pruritic skin disorders
Mechanism Of Action: Dilosyn binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Methdilazine
Synonyms: MD; Methdilazine Hcl; Methdilazine hydrochloride; Methdilazine Monohydrochloride; Methdilazinum [Inn-Latin]; Methilazine hydrochloride; Methodilazine; Metodilazina [Inn-Spanish]
Drug Category: Antihistamines
Drug Type: Small Molecule; Approved
Absorption: Well absorbed in the digestive tract.
Toxicity (Overdose): Symptoms of overdose include clumsiness or unsteadiness, convulsions, drowsiness, dryness of mouth, nose, or throat, feeling faint, flushing or redness of face, hallucinations, muscle spasms (especially of neck and back), restlessness, shortness of breath or troubled breathing, shuffling walk, tic-like movements of head and face, trembling and shaking of hands, and trouble in sleeping.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Dilosyn: Not Available
Chemical IUPAC Name: 10-[(1-methylpyrrolidin-3-yl)methyl]phenothiazine
Chemical Formula: C18H20N2S
Methdilazine on Wikipedia: https://en.wikipedia.org/wiki/Methdilazine
Organisms Affected: Humans and other mammals