Diusemide - General Information
A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. [PubChem]
Pharmacology of Diusemide
Diusemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.
Diusemide for patients
Furosemide is a diuretic (water pill) used to treat fluid retention and high blood pressure. Do not take this medication if you are allergic to sulfa medicine. Notify your physician if you are pregnant or nursing. Notify your physician if you have diabetes mellitus. Blood glucose levels may be increased in patients with diabetes mellitus. Take this medication early in the day. Furosemide may be taken with or without food. Take with food or milk if stomach upset occurs. Notify your physician if you develop weakness, cramps, or nausea. Dizziness or lightheadedness may occur with therapy; avoid sudden changes in posture. Furosemide may cause increased sensitivity to sunlight. Use sunscreens and wear protective clothing until degree of sensitivity is determined.
Furosemide may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination.
Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with furosemide, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.
Furosemide has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.
Lithium generally should not be given with diuretics because they reduce lithium's renal clearance and add a high risk of lithium toxicity.
Furosemide may add to or potentiate the therapeutic effect of other antihypertensive drugs. Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.
Furosemide may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively.
Simultaneous administration of sucralfate and furosemide tablets may reduce the natriuretic and antihypertensive effects of furosemide. Patients receiving both drugs should be observed closely to determine if the desired diuretic and/or antihypertensive effect of furosemide is achieved. The intake of furosemide and sucralfate should be separated by at least two hours.
Tablets, Injection, and Oral Solution
One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency. There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs.
Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of furosemide in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation. Patients receiving both indomethacin and furosemide should be observed closely to determine if the desired diuretic and/or antihypertensive effect of furosemide is achieved.
Furosemide is contraindicated in patients with anuria and in patients with a history of hypersensitivity to furosemide.
Additional information about Diusemide
Diusemide Indication: For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Mechanism Of Action: Diusemide, by inhibiting the reabsorption of sodium and chloride in the ascending limb of the loop of Henle, increases the urinary excretion of sodium, chloride, and water. Diusemide also increases the excretion of potassium, hydrogen, calcium, magnesium, ammonium, and phosphate and, as it inhibits carbonic anhydrase, bicarbonate.
Drug Interactions: Amikacin Increased ototoxicity
Cisplatin Increased ototoxicity
Gentamicin Increased ototoxicity
Kanamycin Increased ototoxicity
Tobramycin Increased ototoxicity
Streptomycin Increased ototoxicity
Netilmicin Increased ototoxicity
Deslanoside Possible electrolyte variations and arrhythmias
Digoxin Possible electrolyte variations and arrhythmias
Digitoxin Possible electrolyte variations and arrhythmias
Ethotoin The hydantoin decreases the effect of furosemide
Fosphenytoin The hydantoin decreases the effect of furosemide
Phenytoin The hydantoin decreases the effect of furosemide
Mephenytoin The hydantoin decreases the effect of furosemide
Ginseng Ginseng decreases the therapeutic effect
Ibuprofen The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic
Indomethacin The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic
Sulindac The NSAID decreases the diuretic and antihypertensive effects of the loop diuretic
Food Interactions: Avoid alcohol.
Avoid excess salt/sodium unless otherwise instructed by your physician.
Increase potassium intake; add a banana or orange juice; unless instructed otherwise.
Take with food to reduce irritation.
Generic Name: Furosemide
Synonyms: Frusemide; Frusemid; Dihydroflumethiazide; Furosemida [Inn-Spanish]; Furosemidu [Polish]; Furosemidum [Inn-Latin]; Furosemid; Fursemid; Fursemida; Fursemide; Metflorylthiazidine; Methforylthiazidine
Drug Category: Diuretics
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 99%
Biotransformation: Not Available
Half Life: 2 hours
Dosage Forms of Diusemide: Solution Intravenous
Chemical IUPAC Name: 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid
Chemical Formula: C12H11ClN2O5S
Furosemide on Wikipedia: https://en.wikipedia.org/wiki/Furosemide
Organisms Affected: Humans and other mammals