Dopram - General Information
A central respiratory stimulant with a brief duration of action. (From Martindale, The Extra Pharmocopoeia, 30th ed, p1225)
Pharmacology of Dopram
Dopram is an analeptic agent (a stimulant of the central nervous system). The respiratory stimulant action is manifested by an increase in tidal volume associated with a slight increase in respiratory rate. A pressor response may result following doxapram administration. Provided there is no impairment of cardiac function, the pressor effect is more marked in hypovolemic than in normovolemic states. The pressor response is due to the improved cardiac output rather than peripheral vasoconstriction. Following doxapram administration, an increased release of catecholamines has been noted.
Dopram for patients
Administration of doxapram to patients who are receiving sympathomimetic or monoamine oxidase inhibiting drugs may result in an additive pressor effect.
In patients who have received muscle relaxants, doxapram may temporarily mask the residual effects of muscle relaxant drugs.
In patients who have received general anesthesia utilizing a volatile agent known to sensitize the myocardium to catecholamines, administration of doxapram should be delayed until the volatile agent has been excreted in order to lessen the potential for arrhythmias, including ventricular tachycardia and ventricular fibrillation.
Due to its benzyl alcohol content, doxapram injection is contraindicated in neonates.
Doxapram should not be used in patients with epilepsy or other convulsive disorders.
Doxapram is contraindicated in patients with mechanical disorders of ventilation such as mechanical obstruction, muscle paresis, flail chest, pneumothorax, acute bronchial asthma, pulmonary fibrosis or other conditions resulting in restriction of chest wall, muscles of respiration or alveolar expansion.
Doxapram is contraindicated in patients with evidence of head injury or cerebral vascular accident and in those with significant cardiovascular impairment, severe hypertension, or known hypersensitivity to the drug or any of the injection components.
Additional information about Dopram
Dopram Indication: For use as a temporary measure in hospitalized patients with acute respiratory insufficiency superimposed on chronic obstructive pulmonary disease.
Mechanism Of Action: Dopram produces respiratory stimulation mediated through the peripheral carotid chemoreceptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Doxapram
Synonyms: Not Available
Drug Category: Central Nervous System Stimulants; Respiratory System Agents
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Intravenous LD50 values in the mouse and rat were approximately 75 mg/kg and in the cat and dog were 40 to 80 mg/kg. Symptoms of overdosage are extensions of the pharmacologic effects of the drug. Excessive pressor effect, tachycardia, skeletal muscle hyperactivity, and enhanced deep tendon reflexes may be early signs of overdosage.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Dopram: Injection, solution Intravenous
Chemical IUPAC Name: 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-di(phenyl)pyrrolidin-2-one
Chemical Formula: C24H30N2O2
Doxapram on Wikipedia: https://en.wikipedia.org/wiki/Doxapram
Organisms Affected: Humans and other mammals