Duract - General Information

Duract is a nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use. Ophthalmic NSAIDs are becoming a cornerstone for the management of ocular pain and inflammation. Their well-characterized anti-inflammatory activity, analgesic property, and established safety record have also made NSAIDs an important tool to optimize surgical outcomes.


Pharmacology of Duract

Duract ophthalmic solution is a sterile, topical, nonsteroidal anti-inflammatory drug (NSAID) for ophthalmic use.


Duract for patients

XIBROM ophthalmic solution should not be administered while wearing contact lenses.


Duract Interactions

No information provided.


Duract Contraindications

XIBROM ophthalmic solution is contraindicated in patients with known hypersensitivity to any ingredient in the formulation.


Additional information about Duract

Duract Indication: For the treatment of postoperative inflammation in patients who have undergone cataract extraction.
Mechanism Of Action: The mechanism of its action is thought to be due to its ability to block prostaglandin synthesis by inhibiting cyclooxygenase 1 and 2. Prostaglandins have been shown in many animal models to be mediators of certain kinds of intraocular inflammation. In studies performed in animal eyes, prostaglandins have been shown to produce disruption of the blood-aqueous humor barrier, vasodilation, increased vascular permeability, leukocytosis, and increased intraocular pressure.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Bromfenac
Synonyms: Bromfenac sodium
Drug Category: Analgesics; Anti-Inflammatory Agents, Non-Steroidal
Drug Type: Small Molecule; Approved

Other Brand Names containing Bromfenac: Xibrom; Duract;
Absorption: The plasma concentration of bromfenac following ocular administration in humans is unknown.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Duract: Solution / drops Ophthalmic
Chemical IUPAC Name: 2-[2-amino-3-(4-bromobenzoyl)phenyl]acetic acid
Chemical Formula: C15H12BrNO3
Bromfenac on Wikipedia: Not Available
Organisms Affected: Humans and other mammals