Enterfram - General Information

A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)


Pharmacology of Enterfram

Enterfram is used for the treatment of bacterial eye infections such as conjunctivitis. Enterfram is an antibiotic. It is not active against fungi, viruses and most kinds of anaerobic bacteria. Enterfram works by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Enterfram is useful primarily in infections involving aerobic bacteria bacteria.


Additional information about Enterfram

Enterfram Indication: For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal
Mechanism Of Action: Enterfram binds to specific 30S-subunit proteins and 16S rRNA, four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Framycetin
Synonyms: Framycetinum [Inn-Latin]; Neomycin B; Streptothricin B
Drug Category: Anti-Bacterial Agents; Antibiotics
Drug Type: Small Molecule; Approved

Other Brand Names containing Framycetin: Actilin; Actiline; Antibiotique; Dekamycin V; Enterfram; Fradiomycin B; Framygen; Nebramycin X; Negamicin; Neomycin A; Soframycin; Soframycin Ophthalmic; Soframycine;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Enterfram: Solution / drops Ophthalmic
Dressing Topical
Ointment Ophthalmic
Chemical IUPAC Name: (2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
Chemical Formula: C23H46N6O13
Framycetin on Wikipedia: Not Available
Organisms Affected: Enteric bacteria and other eubacteria