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Ethmozine

Ethmozine - General Information

An antiarrhythmia agent used primarily for ventricular rhythm disturbances. [PubChem]

 

Pharmacology of Ethmozine

Ethmozine is used to treat irregular heartbeats (arrhythmias) and to maintain a normal heart rate. It acts on the heart muscle to improve the heart's rhythm. Ethmozine has potent local anesthetic activity and membrane stabilizing effect. Decreases excitability, conduction velocity, and automaticity as a result of slowed atrioventricular (AV) nodal and His-Purkinje conduction. Decreases the action potential duration (APD) in Purkinje fibers; also decreases the effective refractory period (ERP) but to a lesser extent than the APD, so the ERP/APD ratio is increased. Decreases the maxiumum rate of Phase 0 depolarization (V max ), but does not affect action potential amplitude or maximum diastolic potential. Does not affect atrial, AV nodal, or left ventricular refractory periods and has minimal effect on ventricular repolarization (evidenced by the overall decrease in JT interval). Has no effect on sinoatrial (SA) nodal or intra-atrial conduction and only minimal effect on sinus cycle length and sinus node recovery time. In the Vaughan Williams classification of antiarrhythmics, moricizine is considered to be a class I agent. It has properties of class IA, IB, and IC agents but does not clearly belong to any of the three subclasses. It has less effect on the slope of phase 0 and a greater effect on action potential duration and effective refractory period than class IC agents.

 

Ethmozine for patients

This medication is usually started in the hospital where your dose can be closely checked. It is important to take this medication exactly as prescribed. Do not increase or decrease your dose without your doctor's approval. This medication works best when there is a constant level of the drug in your body. To do this, take each dose exactly as prescribed at evenly spaced intervals throughout the day and night. Try to take each dose at the same time each day. Do not stop taking this medication without consulting your doctor. Some conditions may become worse when the drug is suddenly stopped.

 

Ethmozine Interactions

May interact with cimetidine, digoxin, medicines to control heart rhythm, sevelamer, and theophylline.

 

Ethmozine Contraindications

 

Additional information about Ethmozine

Ethmozine Indication: Used to treat irregular heartbeats (arrhythmias) and maintain a normal heart rate.
Mechanism Of Action: Ethmozine works by inhibiting the rapid inward sodium current across myocardial cell membranes.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Moricizine
Synonyms: Moracizina [INN-Spanish]; Moracizinum [INN-Latin]; Moracizine
Drug Category: Anti-Arrhythmia Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Moricizine: Ethmozine;
Absorption: Well absorbed, absorption is complete within 2 to 3 hours. Significant first-pass metabolism results in an absolute bioavailability of approximately 38%. Administration within 30 minutes after a meal slows the rate, but does not affect the extent of absorption, although peak plasma concentrations are reduced.
Toxicity (Overdose): Symptoms of overdose include vomiting, unconsciousness, and severe low blood pressure.
Protein Binding: Approximately 95%.
Biotransformation: Hepatic and extensive, to at least 26 metabolites, none accounting for as much as 1% of the administered dose. Two metabolites may be pharmacologically active but are present in extremely small quantities. Moricizine induces its own metabolism (it induces hepatic cytochrome P-450 activity).
Half Life: 2 hours (range 1.5-3.5 hours).
Dosage Forms of Ethmozine: Not Available
Chemical IUPAC Name: ethyl N-[10-(3-morpholin-4-ylpropanoyl)phenothiazin-2-yl]carbamate
Chemical Formula: C22H25N3O4S
Moricizine on Wikipedia: https://en.wikipedia.org/wiki/Moricizine
Organisms Affected: Humans and other mammals