Fludara - General Information

Fludara (marketed as fludarabine phosphate under the trade name Fludara) is a chemotherapy drug used in the treatment of hematological malignancies. [Wikipedia]


Pharmacology of Fludara

Fludara is a chemotherapy drug used in the treatment of chronic lymphocytic leukemia. It acts at DNA polymerase alpha, ribonucleotide reductase and DNA primase, results in the inhibition of DNA synthesis, and destroys the cancer cells.


Fludara for patients

FLUDARA FOR INJECTION is a potent antineoplastic agent with potentially significant toxic side effects. Patients undergoing therapy should be closely observed for signs of hematologic and nonhematologic toxicity. Periodic assessment of peripheral blood counts is recommended to detect the development of anemia, neutropenia and thrombocytopenia.


Fludara Interactions

The use of FLUDARA FOR INJECTION in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity.


Fludara Contraindications

FLUDARA FOR INJECTION is contraindicated in those patients who are hypersensitive to this drug or its components.


Additional information about Fludara

Fludara Indication: For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
Mechanism Of Action: Fludara phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Drug Interactions: Dipyridamole Dipyridamole decreases the effect of fludarabine
Pentostatin Unacceptable pulmonary toxicity
Food Interactions: Take without regard to meals.
Food slightly increases product bioavailability.
Generic Name: Fludarabine
Synonyms: FAMP; Fludarabine 5'-monophosphate; Fludarabine monophosphate; Fludarabine phosphate
Drug Category: Immunosuppressive Agents; Antimetabolites; Antineoplastic Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Fludarabine: Fludara; Fludura;
Absorption: Bioavailability is 55% following oral administration.
Toxicity (Overdose): Not Available
Protein Binding: 19-29%
Biotransformation: Not Available
Half Life: 20 hours
Dosage Forms of Fludara: Tablet Oral
Powder, for solution Intravenous
Chemical IUPAC Name: [(2R,3S,4S,5R)-5-(6-amino-2-fluoropurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl dihydrogen phosphate
Chemical Formula: C10H13FN5O7P
Fludarabine on Wikipedia:
Organisms Affected: Humans and other mammals