Fluorescein disodium salt dihydrate - General Information
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)
Pharmacology of Fluorescein disodium salt dihydrate
Fluorescein disodium salt dihydrate for patients
Skin will attain a temporary yellowish discoloration. Urine attains a bright yellow color. Discoloration of the skin fades in 6 to 12 hours; urine fluorescence in 24 to 36 hours.
Fluorescein disodium salt dihydrate Interactions
Fluorescein disodium salt dihydrate Contraindications
Contraindicated in those persons who have shown hypersensitivity to any component of this preparation.
Additional information about Fluorescein disodium salt dihydrate
Fluorescein disodium salt dihydrate Indication: For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
Mechanism Of Action: Fluorescein disodium salt dihydrate sodium is used extensively as a diagnostic tool in the field of ophthalmology. Fluorescein disodium salt dihydrate is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Fluorescein disodium salt dihydrate angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Fluorescein
Synonyms: Not Available
Drug Category: Contrast Media
Drug Type: Small Molecule; Approved
Absorption: Rapidly distributed
Toxicity (Overdose): Not Available
Protein Binding: 85%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Fluorescein disodium salt dihydrate: Solution Intravenous
Chemical IUPAC Name: 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Chemical Formula: C20H12O5
Fluorescein on Wikipedia: https://en.wikipedia.org/wiki/Fluorescein
Organisms Affected: Humans and other mammals