Freezone - General Information
A compound obtained from the bark of the white willow and wintergreen leaves, and also prepared synthetically. It has bacteriostatic, fungicidal, and keratolytic actions. Its salts, the salicylates, are used as analgesics.
Pharmacology of Freezone
Salicylic acid treats acne by causing skin cells to slough off more readily, preventing pores from clogging up. This effect on skin cells also makes salicylic acid an active ingredient in several shampoos meant to treat dandruff. Use of straight salicylic solution may cause hyperpigmentation on unpretreated skin for those with darker skin types (Fitzpatrick phototypes IV, V, VI), as well as with the lack of use of a broad spectrum sunblock. Subsalicylate in combination with bismuth form the popular stomach relief aid known commonly as Pepto-Bismol. When combined the two key ingredients help control diarrhea, nausea, heartburn, and even gas. It is also very mildly anti-biotic.
Additional information about Freezone
Freezone Indication: Key additive in many skin-care products for the treatment of acne, psoriasis, callouses, corns, keratosis pilaris and warts.
Mechanism Of Action: Salicylic acid directly and irreversibly inhibits the activity of both types of cyclo-oxygenases (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. Salicylate may competitively inhibit prostaglandin formation. Salicylate's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms. Salicylic acid is a key ingredient in many skin-care products for the treatment of acne, psoriasis, calluses, corns, keratosis pilaris, and warts. It works by causing the cells of the epidermis to slough off more readily, preventing pores from clogging up, and allowing room for new cell growth. Because of its effect on skin cells, salicylic acid is used in several shampoos used to treat dandruff. Salicylic acid is also used as an active ingredient in gels which remove verrucas (plantar warts). Salicylic acid inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD) and noncompetitively with UDPG. It also competitively inhibits the transferring of glucuronyl group of uridine-5-phosphoglucuronic acid (UDPGA) to the phenolic acceptor. The wound-healing retardation action of salicylates is probably due mainly to its inhibitory action on mucopolysaccharide synthesis.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Salicyclic acid
Synonyms: 2-Carboxyphenol; 2-Hydroxybenzenecarboxylic acid; 2-Hydroxybenzoic acid; Acido salicilico; O-carboxyphenol; O-hydroxybenzoic acid; Orthohydroxybenzoic acid; Phenol-2-carboxylic acid; SA; Salicylate; Salicylic acid
Drug Category: Anti-Infective Agents; Antifungal Agents; Keratolytic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Salicyclic acid: Advanced pain relief callus removers; Advanced pain relief corn removers; Clear away wart remover; Compound W; Dr. Scholl's Callus Removers; Dr. Scholl's Corn Removers; Dr. Scholl's Wart Remover Kit; Duofil Wart Remover; Duoplant; Freezone; Ionil; Keralyt; Kyselina 2-hydroxybenzoova; Kyselina salicylova; Psoriacid-s-stift; Retarder SAX; Retarder W; Rutranex; SAX; Salicylic acid collodion; Salicylic acid soap; Saligel; Salonil; Stri-dex;
Absorption: Not Available
Toxicity (Overdose): Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Freezone: Gel Topical
Solution / drops Oral
Chemical IUPAC Name: 2-hydroxybenzoic acid
Chemical Formula: C7H6O3
Salicyclic acid on Wikipedia: https://en.wikipedia.org/wiki/Salicyclic_acid
Organisms Affected: Humans and other mammals