Funduscein-25 - General Information
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium, such as the aqueous humor, and is used therapeutically as a diagnostic aid in corneal injuries and corneal trauma. It has been approved by FDA for use in externally applied drugs and cosmetics. (From Merck Index, 12th ed; American Medical Association Drug Evaluations; 1995, p2275)
Pharmacology of Funduscein-25
Funduscein-25 for patients
Skin will attain a temporary yellowish discoloration. Urine attains a bright yellow color. Discoloration of the skin fades in 6 to 12 hours; urine fluorescence in 24 to 36 hours.
Contraindicated in those persons who have shown hypersensitivity to any component of this preparation.
Additional information about Funduscein-25
Funduscein-25 Indication: For diagnostic imaging. Primarily indicated in diagnostic fluorescein angiography or angioscopy of the fundus and of the iris vasculature.
Mechanism Of Action: Funduscein-25 sodium is used extensively as a diagnostic tool in the field of ophthalmology. Funduscein-25 is a fluorescent compound or fluorophore having a maximum absorbance of 494 m and an emission maximum of 521 nm. The yellowish-green fluorescence of the compound can be used to demarcate the vascular area under observation, distinguishing it from adjacent areas. It is applied topically in the form of a drop or it can be injected intravenously to produce a fluorescein angiogram. Topical fluorescein is a useful tool in the diagnosis of corneal abrasions, corneal ulcers, herpetic corneal infections, and dry eye. Funduscein-25 angiography is used to diagnose and categorize macular degeneration, diabetic retinopathy, inflammatory intraocular conditions, and intraocular tumors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Fluorescein
Synonyms: Not Available
Drug Category: Contrast Media
Drug Type: Small Molecule; Approved
Absorption: Rapidly distributed
Toxicity (Overdose): Not Available
Protein Binding: 85%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Funduscein-25: Solution Intravenous
Chemical IUPAC Name: 3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
Chemical Formula: C20H12O5
Fluorescein on Wikipedia: https://en.wikipedia.org/wiki/Fluorescein
Organisms Affected: Humans and other mammals