Gastrozepin - General Information
An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as cimetidine and ranitidine. It is generally well tolerated by patients. [PubChem]
Pharmacology of Gastrozepin
Gastrozepin belongs to a group of medications called antispasmodics/anticholinergics. These medications are used to relieve cramps or spasms of the stomach, intestines, and bladder. Gastrozepin is used to treat duodenal or stomach ulcers or intestine problems. It can be used together with antacids or other medicine in the treatment of peptic ulcer. It may also be used to prevent nausea, vomiting, and motion sickness.
Gastrozepin for patients
Check with your doctor before you take Pirenzepine. It may cause blurry vision and dizziness, which may affect driving, operating machinery and other
activities. It may also cause dryness of the mouth, nose and throat.
Do not change the dose or stop Pirenzepine without consulting your doctor. The dose of Pirenzepine needs to reduced gradually to prevent the
withdrawal side effects.
Pirenzepine may interact with the following drugs, which may affect the effect of Pirenzepine or whose effects may be affected.
- Diarrhea medicine containing kaolin or attapulgite
- Central nervous system (CNS) depressants
- Other anticholinergics
- Tricyclic antidepressants (e.g., Elavil, Asendin, Anafranil, Pertofrane, Sinequan, Tofranil, Aventyl, Surmontil)
- Potassium chloride (e.g., Kay Ciel)
Additional information about Gastrozepin
Gastrozepin Indication: For the treatment of peptic ulcer, gastric ulcer, and duodenal ulcer.
Mechanism Of Action: Gastrozepin is a muscarinic receptor antagonist and binds to the muscarinic acetylcholine receptor. The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Pirenzepine
Synonyms: Not Available
Drug Category: Anti-Ulcer Agents; Antimuscarinics; Antispasmodics
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Gastrozepin: Not Available
Chemical IUPAC Name: 11-[2-(4-methylpiperazin-1-yl)acetyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Chemical Formula: C19H21N5O2
Pirenzepine on Wikipedia: https://en.wikipedia.org/wiki/Pirenzepine
Organisms Affected: Humans and other mammals