Glaucol - General Information
A carbonic anhydrase inhibitor that is used in the treatment of glaucoma. [PubChem]
Pharmacology of Glaucol
Glaucol is an oral carbonic anhydrase inhibitor indicated for adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure. Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow).
Glaucol for patients
Caution is advised in patients receiving concomitant high-dose aspirin and carbonic anhydrase inhibitors, as anorexia, tachypnea, lethargy and coma have been rarely reported due to a possible drug interaction.
DARANIDE is contraindicated in hepatic insufficiency, renal failure, adrenocortical insufficiency, hyperchloremic acidosis, or in conditions in which serum levels of sodium or potassium are depressed. DARANIDE should not be used in patients with severe pulmonary obstruction who are unable to increase their alveolar ventilation since their acidosis may be increased.
DARANIDE is contraindicated in patients who are hypersensitive to this product.
Additional information about Glaucol
Glaucol Indication: For adjunctive treatment of: chronic simple (open-angle) glaucoma, secondary glaucoma, and preoperatively in acute angle-closure glaucoma where delay of surgery is desired in order to lower intraocular pressure
Mechanism Of Action: Carbonic anhydrase inhibitors reduce intraocular pressure by partially suppressing the secretion of aqueous humor (inflow), although the mechanism by which they do this is not fully understood. Evidence suggests that HCO3- ions are produced in the ciliary body by hydration of carbon dioxide under the influence of carbonic anhydrase and diffuse into the posterior chamber which contains more Na+ and HCO3- ions than does plasma and consequently is hypertonic. Water is then attracted to the posterior chamber by osmosis, resulting in a drop in pressure.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dichlorphenamide
Synonyms: Diclofenamida [Inn-Spanish]; Diclofenamide; Diclofenamidum [Inn-Latin]; Dichlorphenamid; Dichlorophenamide; Dichlofenamide
Drug Category: Antiglaucomic Agents; Ophthalmics
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: 55%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Glaucol: Tablet Oral
Chemical IUPAC Name: 4,5-dichlorobenzene-1,3-disulfonamide
Chemical Formula: C6H6Cl2N2O4S2
Dichlorphenamide on Wikipedia: https://en.wikipedia.org/wiki/Dichlorphenamide
Organisms Affected: Humans and other mammals