HSDB 223 - General Information
HSDB 223 is a molecule containing the sulfonamide functional group attached to an aniline. [Wikipedia]
Pharmacology of HSDB 223
HSDB 223 is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
HSDB 223 for patients
Sulfonamides (sul-FON-a-mides), or sulfa medicines, are used to treat bacterial infections. They work by killing bacteria or preventing their growth.
Vaginal sulfonamides are used to treat bacterial infections. These medicines may also be used for other problems as determined by your doctor.
- Inform you doctor if you have ever had any unusual or allergic reaction to any of the sulfa medicines, furosemide (e.g., Lasix) or thiazide diuretics (water pills), oral antidiabetics (diabetes medicine you take by mouth), or glaucoma medicine you take by mouth (for example, acetazolamide [e.g., Diamox], dichlorphenamide [e.g., Daranide], or methazolamide [e.g., Neptazane]).
- Vaginal sulfonamides are absorbed through the vagina into the bloodstream and appear in the bloodstream of the fetus so if you are pragnent inform you doctor
- Vaginal sulfonamides are absorbed through the vagina into the bloodstream and pass into the breast milk. Use is not recommended in nursing mothers.
- Medicine is only for the use of adults not for children
- Inform your doctor if you have other medical problems.
HSDB 223 Interactions
This medicine is generally safe with other medications, but patient should consult doctor or pharmacist if patient is taking a blood thinner (anticoagulant), cyclosporin, phenytoin, or methotrexate.
HSDB 223 Contraindications
Additional information about HSDB 223
HSDB 223 Indication: For the treatment of vulvovaginitis caused by Candida albicans.
Mechanism Of Action: HSDB 223 is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sulfanilamide
Synonyms: P-Aminobenzenesulfamide; P-Sulfamoylaniline; P-Sulfamidoaniline; P-Anilinesulfonamide; P-Aminophenylsulfonamide; P-Aminobenzensulfonamide; P-Aminobenzenesulfonylamide; P-Aminobenzenesulfonamide; PABS; Sulfanilimidic Acid; Sulfonylamide; Sulphanilamide; Sulphonamide
Drug Category: Anti-Bacterial Agents; Homeopathic Agents
Drug Type: Small Molecule; Approved
Absorption: Sulfonamides are absorbed through the vaginal mucosa. There are no pharmacokinetic data available describing how much of an intravaginal dose reaches the systemic circulation.
Toxicity (Overdose): Oral, mouse LD50 = 3700 mg/kg; Intravenous, mouse LD50 = 621 mg/kg; Oral, rabbit LD50 = 1300 mg/kg. Side effects include itching, burning, skin rash, redness, swelling, or other sign of irritation not present before use of this medicine and long-term use of sulfonamides may cause cancer of the thyroid gland.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of HSDB 223: Liquid Oral
Chemical IUPAC Name: 4-aminobenzenesulfonamide
Chemical Formula: C6H8N2O2S
Sulfanilamide on Wikipedia: https://en.wikipedia.org/wiki/Sulfanilamide
Organisms Affected: Candida albicans and other yeasts