HSDB 817 - General Information
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as flavin mononucleotide and flavin-adenine dinucleotide. [PubChem]
Pharmacology of HSDB 817
HSDB 817 or vitamin B2 is an easily absorbed, water-soluble micronutrient with a key role in maintaining human health. Like the other B vitamins, it supports energy production by aiding in the metabolising of fats, carbohydrates, and proteins. Vitamin B2 is also required for red blood cell formation and respiration, antibody production, and for regulating human growth and reproduction. It is essential for healthy skin, nails, hair growth and general good health, including regulating thyroid activity. HSDB 817 also helps in the prevention or treatment of many types of eye disorders, including some cases of cataracts.
HSDB 817 for patients
HSDB 817 Interactions
Interactions for Vitamin B2 (Riboflavin):
Alcohol - impairs the intestinal absorption of riboflavin
Antidepressants (tricyclics or phenothiazines) - requirements for riboflavin may be increased in patients receiving these medications.
Probenecid - concurrent use decreases gastrointestinal absorption of riboflavin; requirements for riboflavin may be increased in patients receiving probenecid.
HSDB 817 Contraindications
Additional information about HSDB 817
HSDB 817 Indication: For the treatment of ariboflavinosis (vitamin B2 deficiency).
Mechanism Of Action: Binds to riboflavin hydrogenase, riboflavin kinase, and riboflavin synthase. HSDB 817 is the precursor of flavin mononucleotide (FMN, riboflavin monophosphate) and flavin adenine dinucleotide (FAD). The antioxidant activity of riboflavin is principally derived from its role as a precursor of FAD and the role of this cofactor in the production of the antioxidant reduced glutathione. Reduced glutathione is the cofactor of the selenium-containing glutathione peroxidases among other things. The glutathione peroxidases are major antioxidant enzymes. Reduced glutathione is generated by the FAD-containing enzyme glutathione reductase.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Riboflavin
Synonyms: Vitamin B2; Riboflavina [Inn-Spanish]; Riboflavine [Inn-French]; Riboflavinum [Inn-Latin]; Russupteridine Yellow III; Vitamin G; Vitamin Bi; Lactoflavin; Lactoflavine
Drug Category: Radiation-Sensitizing Agents; Vitamins (Vitamin B Complex)
Drug Type: Small Molecule; Nutraceutical; Approved
Absorption: Vitamin B2 is readily absorbed from the upper gastrointestinal tract.
Toxicity (Overdose): Not Available
Protein Binding: 60%
Half Life: 66-84 minutes
Dosage Forms of HSDB 817: Not Available
Chemical IUPAC Name: 7,8-dimethyl-10-[(2R,3R,4S)-2,3,4,5-tetrahydroxypentyl]benzo[g]pteridine-2,4-dione
Chemical Formula: C17H20N4O6
Riboflavin on Wikipedia: https://en.wikipedia.org/wiki/Riboflavin
Organisms Affected: Humans and other mammals