Halotestin - General Information
An anabolic steroid that has been used in the treatment of male hypogonadism, delayed puberty in males, and in the treatment of breast neoplasms in women. [PubChem]
Pharmacology of Halotestin
Halotestin is a synthetic androgen, or male hormone, similar to testosterone. Halotestin works by attaching itself to androgen receptors; this causes it to interact with the parts of the cell involved in the making of proteins. It may cause an increase in the synthesis of some proteins or a decrease in the synthesis of others. These proteins have a variety of effects, including blocking the growth of some types of breast cancer cells, stimulating cells that cause male sexual characteristics, and stimulating the production of red blood cells.
Halotestin for patients
Patients should be instructed to report any of the following: nausea, vomiting, changes in skin color, and ankle swelling.
Males should be instructed to report too frequent or persistent erections of the penis and females any hoarseness, acne, changes in menstrual periods or increase in facial hair.
Androgens may increase sensitivity to oral anticoagulahts. Dosage of the anticoagulant may require reduction in order to maintain satisfactory therapeutic hypoprothrombinemia.
Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.
In diabetic patients, the metabolic effects of androgens may decrease blood glucose and therefore, insulin requirements.
- Known hypersensitivity to the drug
- Males with carcinoma of the breast
- Males with known or suspected carcinoma of the prostate gland
- Women known or suspected to be pregnant
- Patients with serious cardiac, hepatic or renal disease
Additional information about Halotestin
Halotestin Indication: In males, used as replacement therapy in conditions associated with symptoms of deficiency or absence of endogenous testosterone. In females, for palliation of androgenresponsive recurrent mammary cancer in women who are more than one year but less than five years postmenopausal.
Mechanism Of Action: Halotestin is a synthetic androgenic anabolic steroid and is approximately 5 times as potent as natural methyltestosterone. Like testosterone and other androgenic hormones, fluoxymesterone binds to the androgen receptor. It produces retention of nitrogen, potassium, and phosphorus; increases protein anabolism; and decreases amino acid catabolism. The antitumour activity of fluoxymesterone appears related to reduction or competitive inhibition of prolactin receptors or estrogen receptors or production.
Drug Interactions: Anisindione The androgen increases the anticoagulant effect
Dicumarol The androgen increases the anticoagulant effect
Acenocoumarol The androgen increases the anticoagulant effect
Warfarin The androgen increases the anticoagulant effect
Food Interactions: Take with food.
Generic Name: Fluoxymesterone
Synonyms: Fluossimesterone [DCIT]; Fluoximesterona [INN-Spanish]; Fluoximesterone; Fluoximesteronum; Fluoxymesteronum [INN-Latin]; Fluoxymestrone; Androfluorene; Androfluorone; FXM
Drug Category: Anabolic Agents; Antineoplastic Agents, Hormonal
Drug Type: Small Molecule; Illicit; Approved
Absorption: Oral absorption is less than 44%.
Toxicity (Overdose): Side effects include virilization (masculine traits in women), acne, fluid retention, and hypercalcemia.
Protein Binding: Very high (99%) with 80% to sex hormone binding globulin, 19% to albumin.
Biotransformation: Presence of 17-alpha alkyl group reduces susceptibility to hepatic enzyme degradation, which slows metabolism and allows oral administration. Inactivation of testosterone occurs primarily in the liver
Half Life: 9.2 hours
Dosage Forms of Halotestin: Tablet Oral
Chemical IUPAC Name: (8S,9R,10S,11S,13S,14S,17S)-9-fluoro-11,17-dihydroxy-10,13,17-trimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one
Chemical Formula: C20H29FO3
Fluoxymesterone on Wikipedia: https://en.wikipedia.org/wiki/Fluoxymesterone
Organisms Affected: Humans and other mammals