Hexachlorophane - General Information
A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Pharmacology of Hexachlorophane
Hexachlorophane, a detergent cleanser, is an antibacterial sudsing emulsion for topical administration. It is a bacteriostatic cleansing agent. It cleanses the skin thoroughly and has bacteriostatic action against staphylococci and other gram-positive bacteria. Cumulative antibacterial action develops with repeated use. Cleansing with alcohol or soaps containing alcohol removes the antibacterial residue.
Hexachlorophane for patients
No information available.
Do not use on burned or denuded skin; as an occlusive dressing, wet pack or lotion; as vaginal pack or tampon, on mucous membranes or for routine prophylactic total body bathing.
Should not be used on persons hypersensitive to any of its components nor on persons who have demonstrated primary light sensitivity to halogenated phenol derivatives because of the possibility of cross-sensitivity to hexachlorophene.
Additional information about Hexachlorophane
Hexachlorophane Indication: For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Mechanism Of Action: The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Hexachlorophene
Synonyms: Not Available
Drug Category: Anti-Infectives
Drug Type: Small Molecule; Approved
Absorption: Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
Toxicity (Overdose): Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Protein Binding: 92%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Hexachlorophane: Emulsion Topical
Chemical IUPAC Name: 3,4,6-trichloro-2-[(2,3,5-trichloro-6-hydroxyphenyl)methyl]phenol
Chemical Formula: C13H6Cl6O2
Hexachlorophene on Wikipedia: https://en.wikipedia.org/wiki/Hexachlorophene
Organisms Affected: Enteric bacteria and other eubacteria