Hibistat - General Information
A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. [PubChem]
Pharmacology of Hibistat
Hibistat, a topical antimicrobial agent, is bactericidal. Because of its positive charge, the chlorhexidine molecule reacts with the microbial cell surface to destroy the integrity of the cell membrane. This novel mechanism of action makes it highly unlikely for the development of bacterial resistance.
Hibistat for patients
Patients should avoid dental floss at the site of PerioChip insertion for 10 days after placement, because flossing might dislodge the chip. All other oral hygiene may be continued as usual. No restrictions regarding dietary habits are needed. Dislodging of the PerioChip is uncommon; however, patients should be instructed to notify the dentist promptly if the PerioChip dislodges. Patients should also be advised that, although some mild to moderate sensitivity is normal during the first week after placement of PerioChip, they should notify the dentist promptly if pain, swelling, or other problems occur.
No information provided.
PerioChip should not be used in any patient who has a known sensitivity to chlorhexidine.
Additional information about Hibistat
Hibistat Indication: For reduction of pocket depth in patients with adult periodontitis, used as an adjunct to scaling and root planing procedures. Also for prevention of dental caries, oropharyngeal decontamination in critically ill patients, hand hygiene in health-care personnel, general skin cleanser, and catheter site preparation and care.
Mechanism Of Action: Hibistat's antimicrobial effects are associated with the attractions between chlorhexidine (cation) and negatively charged bacterial cells. After chlorhexidine is absorpted onto the organism's cell wall, it disrupts the integrity of the cell membrane and causes the leakage of intracellular components of the organisms.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Chlorhexidine
Synonyms: Chlorhexidin [Czech]; Chlorhexidine Base; Chlorhexidine Gluconate; Chlorhexidinum [Inn-Latin]; Cloresidina [DCIT]; Clorhexidina [Inn-Spanish]; Decanoylacetaldehyde Sodium Sulfide
Drug Category: Anti-Bacterial Agents; Anti-Infectives
Drug Type: Small Molecule; Approved
Absorption: Absorption of chlorhexidine from the gastrointestinal tract is very poor. Additionally, an in vivo study in 18 adult patients found no detectable plasma or urine chlorhexidine concentrations following insertion of four periodontal implants under clinical conditions.
Toxicity (Overdose): LD50= 2g/kg (human, oral); LD50= 3 g/kg (rat, oral); LD50= 2.5 g/kg (mice, oral); LD50= 21 mg/kg (male rat, IV); LD50= 23 mg/kg (female rat, IV); LD50= 25 mg/kg (male mice, IV); LD50= 24 mg/kg (female mice, IV); LD50= 1g/kg (rat, subcutaneous); LD50= 637 mg/kg (male mice, subcutaneous); LD50= 632 mg/kg (female mice, subcutaneous)
Protein Binding: 87%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Hibistat: Liquid Topical
Chemical IUPAC Name: (1E)-2-[6-[[amino-[[amino-[(4-chlorophenyl)amino]methylidene]amino]methylidene]amino]hexyl]-1-[amino-[(4-chlorophenyl)amino]methylidene]guanidine
Chemical Formula: C22H30Cl2N10
Chlorhexidine on Wikipedia: https://en.wikipedia.org/wiki/Chlorhexidine
Organisms Affected: Bacteria