Humalog (Eli Lily) - General Information
Monomeric form of regular insulin hexamer. Absorbed more rapidly than regular insulin. Has a lysine28, proline29 substitution in the B chain
Pharmacology of Humalog (Eli Lily)
Used in the treatment of type I and type II diabetes. The primary activity of insulin is the regulation of glucose metabolism. In muscle and other tissues (except the brain), insulin causes rapid transport of glucose and amino acids intracellularly. It also promotes anabolism, and inhibits protein catabolism. In the liver, insulin promotes the uptake and storage of glucose in the form of glycogen, inhibits gluconeogenesis, and promotes the conversion of excess glucose into fat.
Additional information about Humalog (Eli Lily)
Humalog (Eli Lily) Indication: For treatment of diabetes (type I and II)
Mechanism Of Action: Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism and catabolism.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Insulin Lyspro recombinant
Synonyms: Humalog; Insulin Lispro
Drug Category: Hypoglycemic Agents
Drug Type: Biotech; Approved
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Insulin is predominantly cleared by metabolic degradation via a receptor-mediated process.
Half Life: 30 hours (mammalian reticulocytes, in vitro).
Dosage Forms of Humalog (Eli Lily): Injection, solution Subcutaneous
Chemical IUPAC Name: Human Insulin
Chemical Formula: C257H387N65O76S6
Insulin Lyspro recombinant on Wikipedia: https://en.wikipedia.org/wiki/Insulin_lispro
Organisms Affected: Humans and other mammals