Hytakerol - General Information
A vitamin D that can be regarded as a reduction product of vitamin D2. [PubChem]
Pharmacology of Hytakerol
Hytakerol is hydroxylated in the liver to 25-hydroxydihydrotachysterol, which is the major circulating active form of the drug. It does not undergo further hydroxylation by the kidney and therefore is the analogue of 1, 25-dihydroxyvitamin D. Hytakerol is effective in the elevation of serum calcium by stimulating intestinal calcium absorption and mobilizing bone calcium in the absence of parathyroid hormone and of functioning renal tissue. Hytakerol also increases renal phosphate excretion.
Hytakerol for patients
Administration of thiazide diuretics to hypoparathyroid patients who are concurrently being treated with dihydrotachysterol may cause hypercalcemia.
Contraindicated in patients with hypercalcemia, abnormal sensitivity to the effects of vitamin D, and hypervitaminosis D.
Additional information about Hytakerol
Hytakerol Indication: Used for the treatment of acute, chronic, and latent forms of postoperative tetany, idiopathic tetany, and hypoparathyroidism
Mechanism Of Action: Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves a transcriptional regulator of bone matrix proteins, inducing the expression of osteocalcin and suppressing synthesis of type I collagen. Vitamin D (when bound to the vitamin D receptor) also stimulates the expression of a number of proteins involved in transporting calcium from the lumen of the intestine, across the epithelial cells and into blood. This stimulates intestinal calcium absorption and increases renal phosphate excretion. These are functions that are normally carried out by the parathyroid hormone.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Dihydrotachysterol
Synonyms: Vitamin D4; Dihydrotachysterol
Drug Category: Antihypocalcemic Agents; Antihypoparathyroid Agents; Vitamins (Vitamin D)
Drug Type: Small Molecule; Approved
Other Brand Names containing Dihydrotachysterol: Antitanil; Calcamine; DHT Intensol; Dichystrolum; Dihydral; Dygratyl; Hytakerol; Parterol; Tachystin;
Absorption: Not Available
Toxicity (Overdose): Toxicity associated with dihydrotachysterol is similar to that seen with large doses of vitamin D.
Protein Binding: >99%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Hytakerol: Tablet Oral
Solution, concentrate Oral
Chemical IUPAC Name: (3Z)-3-[(2E)-2-[1-[(E)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylcyclohexan-1-ol
Chemical Formula: C28H46O
Dihydrotachysterol on Wikipedia: https://en.wikipedia.org/wiki/Dihydrotachysterol
Organisms Affected: Humans and other mammals