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Infed

Infed - General Information

Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Infed is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible.

 

Pharmacology of Infed

Iron dextran is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. It is for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Iron is essential to the formation of hemoglobin and to the function and formation of other heme and nonheme compounds. Untreated depletion of iron stores leads to iron-deficient erythropoiesis and, in turn, to iron deficiency anemia.

 

Infed for patients

Patients should be advised of the potential adverse reactions associated with the use of INFeD.

 

Infed Interactions

 

Infed Contraindications

Hypersensitivity to the product. All anemi as not associated with iron deficiency.

 

Additional information about Infed

Infed Indication: For treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or not receiving erythropoietin and in Hemodialysis Dependent (HDD-CKD) and Peritoneal Dialysis Dependent (PDD-CKD) - Chronic Kidney Disease patients receiving an erythropoietin.
Mechanism Of Action: After iron dextran is injected, the circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiological forms of iron, or to a lesser extent to transferrin. This iron which is subject to physiological control replenishes hemoglobin and depleted iron stores.
Drug Interactions: Alendronate Formation of non-absorbable complexes
Ciprofloxacin Formation of non-absorbable complexes
Clodronate Formation of non-absorbable complexes
Demeclocycline Formation of non-absorbable complexes
Doxycycline Formation of non-absorbable complexes
Enoxacin Formation of non-absorbable complexes
Gatifloxacin Formation of non-absorbable complexes
Etidronic acid Formation of non-absorbable complexes
Gemifloxacin Formation of non-absorbable complexes
Grepafloxacin Formation of non-absorbable complexes
Ibandronate Formation of non-absorbable complexes
Levodopa Iron decreases the absorption of dopa derivatives
Levofloxacin Formation of non-absorbable complexes
Levothyroxine Iron decreases the absorption of levothyroxine
Lomefloxacin Formation of non-absorbable complexes
Methacycline Formation of non-absorbable complexes
Methyldopa Iron decreases the absorption of dopa derivatives
Minocycline Formation of non-absorbable complexes
Moxifloxacin Formation of non-absorbable complexes
Trovafloxacin Formation of non-absorbable complexes
Tetracycline Formation of non-absorbable complexes
Temafloxacin Formation of non-absorbable complexes
Risedronate Formation of non-absorbable complexes
Penicillamine The multivalent agent decreases the effect of penicillamine
Pefloxacin Formation of non-absorbable complexes
Oxytetracycline Formation of non-absorbable complexes
Ofloxacin Formation of non-absorbable complexes
Norfloxacin Formation of non-absorbable complexes
Mycophenolate mofetil Oral iron decreases the absorption of mycophenolate-mofetil
Food Interactions: Not Available
Generic Name: Iron Dextran
Synonyms: Dextran iron; Dexferrum
Drug Category: Iron Supplement; Anti-anemic Agents
Drug Type: Small Molecule; Approved
Other Brand Names containing Iron Dextran: Imferon; Infed; Proferdex;
Absorption: The major portion of intramuscular injections of iron dextran is absorbed within 72 hours; most of the remaining iron is absorbed over the ensuing 3 to 4 weeks.
Toxicity (Overdose): LD50 = 500 mg/kg (mouse, IV). Dosages of iron dextran in excess of the requirements for restoration of hemoglobin and replenishment of iron stores may lead to hemosiderosis. Cases of severe, sometimes fatal, allergic reactions (loss of consciousness, collapse, difficulty breathing, hives, swelling, or convulsions) and severe low blood pressure (hypotension) have been reported with the use of iron dextran.
Protein Binding: 100% (after release from dextran)
Biotransformation: Dextran, a polyglucose, is either metabolized or excreted.
Half Life: 5 hours (some indications that it can be as long as 10 hours)
Dosage Forms of Infed: Injection, solution Intravenous
Injection, solution Intramuscular
Chemical IUPAC Name: Iron dextran
Chemical Formula: (FeO.OH.2H2O)478 (Dx.COOH)9
Iron Dextran on Wikipedia: Not Available
Organisms Affected: Humans and other mammals