Navigation

Instotal

Instotal - General Information

Instotal is a histamine H1 antagonist (antihistamine). It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

 

Pharmacology of Instotal

In allergic reactions an allergen interacts with and cross-links surface IgE antibodies on mast cells and basophils. Once the mast cell-antibody-antigen complex is formed, a complex series of events occurs that eventually leads to cell-degranulation and the release of histamine (and other chemical mediators) from the mast cell or basophil. Once released, histamine can react with local or widespread tissues through histamine receptors. Histamine, acting on H1-receptors, produces pruritis, vasodilatation, hypotension, flushing, headache, tachycardia, and bronchoconstriction. Histamine also increases vascular permeability and potentiates pain. Instotal is a histamine H1 antagonist. It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal tract, blood vessels and respiratory tract. It provides effective, temporary relief of sneezing, watery and itchy eyes, and runny nose due to hay fever and other upper respiratory allergies.

 

Instotal for patients

 

Instotal Interactions

Mequitazine can interact with CNS depressant, antichlolinergic, TCA, MAOIs, and alcohol.

 

Instotal Contraindications

  • Prostatic adenoma
  • Closed Angle Glaucoma
  • Paralytic ileus
  • Stenosis of the pylore
  • Myasthenia Gravis
  • Status Asthmaticus
  • Obstructive chronic broncho-pneumopath
  • Hypersensitivity to the Phenothiazines
  • concomitant MAOI therapy
  • Alcohol

 

Additional information about Instotal

Instotal Indication: For the treatment of Hay fever, urticaria (hives) and allergic rhinitis
Mechanism Of Action: Instotal binds to the histamine H1 receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mequitazine
Synonyms: Mequitazina [Inn-Spanish]; Mequitazina [Spanish]; Mequitazinum [Inn-Latin]
Drug Category: Bronchodilator Agents; Histamine H1 Antagonists
Drug Type: Small Molecule; Approved

Other Brand Names containing Mequitazine: Butix; Instotal; Kitazemin; Metaplexan; Mircol; Primalan; Vigigan; Virginan; Zesulan;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Instotal: Not Available
Chemical IUPAC Name: 10-(1-azabicyclo[2.2.2]octan-8-ylmethyl)phenothiazine
Chemical Formula: C20H22N2S
Mequitazine on Wikipedia: https://en.wikipedia.org/wiki/Mequitazine
Organisms Affected: Humans and other mammals