Inversine hydrochloride - General Information
A nicotinic antagonist that is well absorbed from the gastrointestinal tract and crosses the blood-brain barrier. Inversine hydrochloride has been used as a ganglionic blocker in treating hypertension, but, like most ganglionic blockers, is more often used now as a research tool. [PubChem]
Pharmacology of Inversine hydrochloride
Inversine hydrochloride is a potent, oral antihypertensive agent and ganglion blocker, and is a secondary amine. Inversine hydrochloride is indicated for the management of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension. Inversine hydrochloride reduces blood pressure in both normotensive and hypertensive individuals. A small oral dosage often produces a smooth and predictable reduction of blood pressure. Although this antihypertensive effect is predominantly orthostatic, the supine blood pressure is also significantly reduced. Inversine hydrochloride crosses the blood-brain and placental barriers.
Inversine hydrochloride for patients
Inversine hydrochloride Interactions
Patients receiving antibiotics and sulfonamides generally should not be treated with ganglion blockers.
The action of Mecamylamine may be potentiated by anesthesia, other antihypertensive drugs and alcohol.
Inversine hydrochloride Contraindications
Mecamylamine should not be used in mild, moderate, labile hypertension and may prove unsuitable in uncooperative patients. It is contraindicated in coronary insufficiency or recent myocardial infarction. Mecamylamine should be given with great discretion, if at all, when renal insufficiency is manifested by a rising or elevated BUN. The drug is contraindicated in uremia. Patients receiving antibiotics and sulfonamides should generally not be treated with ganglion blockers. Other contraindications are glaucoma, organic pyloric stenosis or hypersensitivity to the product.
Additional information about Inversine hydrochloride
Inversine hydrochloride Indication: For the treatment of moderately severe to severe essential hypertension and in uncomplicated cases of malignant hypertension
Mechanism Of Action: Inversine hydrochloride is a ganglionic blocker which prevents stimulation of postsynaptic receptors by acetylcholine released from presynaptic nerve endings. The hypotensive effect of Inversine hydrochloride is attributed to reduction in sympathetic tone, vasodilation, and reduced cardiac output, and is primarily postural.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mecamylamine
Synonyms: 2-Methylamino-2,3,3-trimethylnorbornane; 2-Methylaminoisocamphane; 3-Methylaminoisocamphane; 3-Methylaminoisocamphane hydrochloride; Mecamylamine Hydrochloride; Mecamilamina
Drug Category: Antihypertensive Agents
Drug Type: Small Molecule; Approved
Absorption: Mecamylamine is almost completely absorbed from the gastrointestinal tract
Toxicity (Overdose): Not Available
Protein Binding: 40%
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Inversine hydrochloride: Tablet Oral
Chemical IUPAC Name: N,5,6,6-tetramethylbicyclo[2.2.1]heptan-5-amine
Chemical Formula: C11H21N
Mecamylamine on Wikipedia: https://en.wikipedia.org/wiki/Mecamylamine
Organisms Affected: Humans and other mammals