J-Sul - General Information
A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. [PubChem]
Pharmacology of J-SulJ-Sul is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus.
J-Sul for patients
Sulfisoxazole should be taken with a full glass of water at regular intervals, 1 hour before and 2 hours after a meal. Finish the medication even if you already feel better. To prevent kidney damage, it is important to maintain adequate hydration, 2-3 L/day of fluids.
Sulfisoxazole may cause some side effects, for example:
- nausea, vomitting, or loss of appetite
- sore throat, fever, vaginal itching or discharge, unusual bruising or bleeding, fatigue
- blood in urine or change in urinary pattern
- swelling of face, lips, or tongue
Talk to you doctor if you plan to become pregnant.
Sulfisoxazole should not be given to patients who are hypersensitive to erythromycin, sulfonamides, or any component of the formulation, who have hepatic dysfunction, and porphyria. It is containdicated in infants of less than 2 months of age.
Sulfisoxazole can not be used concurrently with pimozide or cisapride.
Additional information about J-Sul
J-Sul Indication: For the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections.
Mechanism Of Action: J-Sul is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Sulfisoxazole
Synonyms: Sulfadimethylisoxazole; Sulfafurazol; Sulfafurazole; Sulfaisoxazole; Sulfasoxazole; Sulfisoxazole Dialamine; Sulfisoxasole; Sulfisoxazol; Sulfisoxazole Diolamine; Sulphafurazol; Sulphafurazolum; Sulphafurazole; Sulphofurazole; Sulphisoxazol; Sulphaisoxazole; Sulfofurazole; Sulfisonazole
Drug Category: Anti-Infectives; Sulfonamides
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): LD50=6800 mg/kg (Orally in mice)
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of J-Sul: Tablet Oral
Chemical IUPAC Name: 4-amino-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzenesulfonamide
Chemical Formula: C11H13N3O3S
Sulfisoxazole on Wikipedia: https://en.wikipedia.org/wiki/Sulfisoxazole
Organisms Affected: Enteric bacteria and other eubacteria