Kefroxil - General Information
Long-acting, broad-spectrum, water-soluble, cephalexin derivative. [PubChem]
Pharmacology of Kefroxil
Kefroxil, a first-generation cephalosporin antibiotic, is used to treat urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.
Kefroxil for patients
Patients should be counseled that intibacterial drugs including DURICEF should only be used to treat bacterial infections. They do not treat viral infections (eg. the common cold). When DURICEF is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. Skipping doses or not completing the full course of therapy may (1) decrease the effectiveness of the immediate treatment and (2) increase the likelyhood that bacteria will develop resistance and will not be treatable by DURICEF or other antibacterial drugs in the future.
Drug/Laboratory Test Interactions
Positive direct Coombsí tests have been reported during treatment with the cephalosporin antibiotics. In hematologic studies or in transfusion cross-matching procedures when anti-globulin tests are performed on the minor side or in Coombsí testing of newborns whose mothers have received cephalosporin antibiotics before parturition, it should be recognized that a positive Coombsí test may be due to the drug.
DURICEF (cefadroxil monohydrate, USP) is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.
Additional information about Kefroxil
Kefroxil Indication: For the treatment of the following infections (skin, UTI, ENT) caused by; S. pneumoniae, H. influenzae, staphylococci, S. pyogenes (group A beta-hemolytic streptococci), E. coli, P. mirabilis, Klebsiella sp, coagulase-negative staphylococci and Streptococcus pyogenes
Mechanism Of Action: Like all beta-lactam antibiotics, cefadroxil binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefadroxil interferes with an autolysin inhibitor.
Drug Interactions: Probenecid Probenecid increases the antibiotic's level
Food Interactions: Take without regard to meals.
Food may reduce the digestive problems that sometimes occur.
Generic Name: Cefadroxil
Synonyms: Cefadroxil Monohydrate; Cefradroxil; CDX
Drug Category: Anti-Bacterial Agents; Cephalosporins
Drug Type: Small Molecule; Approved
Absorption: Cefadroxil is well absorbed on oral administration; food does not interfere with its absorption.
Toxicity (Overdose): Nausea, vomiting, diarrhoea, allergic rashes may occur
Protein Binding: Binding rates of cefadroxil were 28.1% by U.F. method
Biotransformation: Not Available
Half Life: 1.5 hours
Dosage Forms of Kefroxil: Capsule Oral
Chemical IUPAC Name: 7-[[2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Chemical Formula: C16H17N3O5S
Cefadroxil on Wikipedia: https://en.wikipedia.org/wiki/Cefadroxil
Organisms Affected: Enteric bacteria and other eubacteria