Ketolar - General Information
A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. [PubChem]
Pharmacology of Ketolar
Ketolar is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. Ketolar is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. The anesthetic state produced by Ketolar has been termed “dissociative anesthesia” in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectively depress the thalamoneocortical system before significantly obtunding the more ancient cerebral centers and pathways (reticularactivating and limbic systems).
Ketolar for patients
As appropriate, especially in cases where early discharge is possible, the duration of ketamine and other drugs employed during the conduct of anesthesia should be considered. The patients should be cautioned that driving an automobile, operating hazardous machinery or engaging in hazardous activities should not be undertaken for 24 hours or more (depending upon the dosage of ketamine and consideration of other drugs employed) after anesthesia.
Prolonged recovery time may occur if barbiturates and/or narcotics are used concurrently with ketamine.
Ketamine is clinically compatible with the commonly used general and local anesthetic agents when an adequate respiratory exchange is maintained.
Ketamine is contraindicated in those in whom a significant elevation of blood pressure would constitute a serious hazard and in those who have shown hypersensitivity to the drug.
Additional information about Ketolar
Ketolar Indication: For use as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation.
Mechanism Of Action: Ketolar has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketolar has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, ketamine does not interact with GABA receptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Ketamine
Synonyms: (-)-Ketamine; (S)-(-)-Ketamine; (S)-Ketamine; CI 581 base; Ketamine HCL; Ketamine Base; l-Ketamine
Drug Category: Analgesics; General Anesthetics
Drug Type: Small Molecule; Approved
Absorption: Rapidly absorbed following parenteral administration.
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Half Life: 2.5-3 hours.
Dosage Forms of Ketolar: Solution Intravenous
Chemical IUPAC Name: 2-(2-chlorophenyl)-2-methylaminocyclohexan-1-one
Chemical Formula: C13H16ClNO
Ketamine on Wikipedia: https://en.wikipedia.org/wiki/Ketamine
Organisms Affected: Humans and other mammals