Levallofano [Dcit] - General Information
An opioid antagonist with properties similar to those of naloxone; in addition it also possesses some agonist properties. It should be used cautiously; levallorphan reverses severe opioid-induced respiratory depression but may exacerbate respiratory depression such as that induced by alcohol or other non-opioid central depressants. (From Martindale, The Extra Pharmacopoeia, 30th ed, p683)
Pharmacology of Levallofano [Dcit]
Levallofano [Dcit], an opioid antagonist similar to naloxone, is used to treat drug overdoses. Levallofano [Dcit] differs from naloxone in that it also possesses some agonist properties. It is an analogue of levelorphanol that counteracts the actions of narcotic analgesics such as morphine. It is used especially in the treatment of respiratory depression due to narcotic overdoses. Levallofano [Dcit] prevents or reverses the effects of opioids including respiratory depression, sedation and hypotension. Also, it can reverse the psychotomimetic and dysphoric effects of agonist-antagonists such as pentazocine.
Levallofano [Dcit] for patients
Levallofano [Dcit] Interactions
Levallofano [Dcit] Contraindications
Levallorphan is contraindicated in patients known to be hypersensitive to it.
Additional information about Levallofano [Dcit]
Levallofano [Dcit] Indication: For the complete or partial reversal of narcotic depression, including respiratory depression, induced by opioids.
Mechanism Of Action: Levallofano [Dcit] antagonizes opioid effects by competing for the same receptor sites. It binds to the opioid mu receptor and the nicotinic acetylcholine receptor alpha2/alpha3.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Levallorphan
Synonyms: Not Available
Drug Category: Analgesic Antagonists; Morphine Antidotes; Antinarcotic Agents; Narcotic Antagonists
Drug Type: Small Molecule; Approved
Absorption: Rapidly absorbed.
Toxicity (Overdose): Oral, rat LD50: 109±4 mg/kg
Protein Binding: Not Available
Half Life: 1 hour
Dosage Forms of Levallofano [Dcit]: Not Available
Chemical IUPAC Name: adamantan-1-amine
Chemical Formula: C19H25NO
Levallorphan on Wikipedia: Not Available
Organisms Affected: Humans and other mammals