Matromicina - General Information
A macrolide antibiotic that is similar to erythromycin.
Pharmacology of Matromicina
Matromicina is a macrolide antibiotic that is similar to erythromycin. It is active in vitro against the following gram-positive organisms: Streptococcus pyogenes and Diplococcus pneumoniae.
Matromicina for patients
Troleandomycin is contraindicated in patients with known hypersensitivity to this antibiotic.
Additional information about Matromicina
Matromicina Indication: For the treatment of Pneumococcal pneumonia due to susceptible strains and group A beta-hemolytic streptococcal infections of the upper respiratory tract.
Mechanism Of Action: Matromicina acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the "P" or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the "A" or acceptor site to the "P" or donor site is prevented, and subsequent protein synthesis is inhibited.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Troleandomycin
Synonyms: Triacetyloleandomycin; Oleandomycin triacetate; Oleandomycin, triacetate (ester); Oleandomycin triacetyl ester; Oleandocetine
Drug Category: Antibacterial Agents; Macrolides
Drug Type: Small Molecule; Approved
Other Brand Names containing Troleandomycin: Cyclamycin; Evramicina; Matromicina; Tao; Treolmicina; Tribiocillina;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include diarrhea, nausea, stomach cramps, and vomiting.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Matromicina: Capsule Oral
Chemical IUPAC Name: [(3R,5S,6S,7R,8S,9R,12R,13S,14S,15R)-6-[(2S,3R,4S,6R)-3-acetyloxy-4-dimethylamino-6-methyloxan-2-yl]oxy-8-[(2R,4S,5S,6S)-5-acetyloxy-4-methoxy-6-methyloxan-2-yl]oxy-5,7,9,12,13,15-hexamethyl-10,16-dioxo-1,11-dioxaspiro[2.13]hexadecan-14-yl] acetate
Chemical Formula: C41H67NO15
Troleandomycin on Wikipedia: https://en.wikipedia.org/wiki/Troleandomycin
Organisms Affected: Enteric bacteria and other eubacteria