Monistat 1 Combination Pack - General Information
An imidazole antifungal agent that is used topically and by intravenous infusion. [PubChem]
Pharmacology of Monistat 1 Combination Pack
Monistat 1 Combination Pack is an anti-fungal medication related to fluconazole (Diflucan), ketoconazole (Nizoral), itraconazole (Sporanox), and clotrimazole (Lotrimin, Mycelex). It is used either on the skin or in the vagina for fungal infections. Monistat 1 Combination Pack was approved by the FDA in 1974. Monistat 1 Combination Pack prevents fungal organisms from producing vital substances required for growth and function. This medication is effective only for infections caused by fungal organisms. It will not work for bacterial or viral infections.
Monistat 1 Combination Pack for patients
Monistat 1 Combination Pack Interactions
Monistat 1 Combination Pack Contraindications
When used by a person taking the anticoagulant medication warfarin, Miconazole may cause an adverse reaction which can lead to excessive bleeding or bruising.
Additional information about Monistat 1 Combination Pack
Monistat 1 Combination Pack Indication: For topical application in the treatment of tinea pedis (athlete’s foot), tinea cruris, and tinea corporis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, in the treatment of cutaneous candidiasis (moniliasis), and in the treatment of tinea versicolor.
Mechanism Of Action: Monistat 1 Combination Pack interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Monistat 1 Combination Pack may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Drug Interactions: Warfarin Vaginal miconazole increases the anticoagulant effect
Acenocoumarol Vaginal miconazole increases the anticoagulant effect
Dicumarol Vaginal miconazole increases the anticoagulant effect
Anisindione Vaginal miconazole increases the anticoagulant effect
Food Interactions: Not Available
Generic Name: Miconazole
Drug Category: Antifungal Agents
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Oral, mouse: LD50 = 3800 mg/kg; Oral, rat: LD50 = 3 gm/kg. Ingestion of the amounts of the components contained in a tube of cream are unlikely to produce overdosage and toxic effects.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Monistat 1 Combination Pack: Aerosol Topical
Chemical IUPAC Name: 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
Chemical Formula: C18H14Cl4N2O
Miconazole on Wikipedia: https://en.wikipedia.org/wiki/Miconazole
Organisms Affected: Fungi, yeast and protozoans