Myotonine Chloride - General Information
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Myotonine Chloride is generally used to increase smooth muscle tone, as in the GI tract following abdominal surgery or in urinary retention in the absence of obstruction. It may cause hypotension, cardiac rate changes, and bronchial spasms. [PubChem]
Pharmacology of Myotonine Chloride
Myotonine Chloride is a parasympathomimetic (cholinergic) used for the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention. Myotonine Chloride, a cholinergic agent, is a synthetic ester which is structurally and pharmacologically related to acetylcholine. It increases the tone of the detrusor urinae muscle, usually producing a contraction sufficiently strong to initiate micturition and empty the bladder. It stimulates gastric motility, increases gastric tone, and often restores impaired rhythmic peristalsis. Myotonine Chloride chloride is not destroyed by cholinesterase and its effects are more prolonged than those of acetytcholine.
Myotonine Chloride for patients
Bethanechol chloride tablets should preferably be taken one hour before or two hours after meals to avoid nausea or vomiting. Dizziness, lightheadedness or fainting may occur, especially when getting up from a lying or sitting position.
Myotonine Chloride Interactions
Special care is required if this drug is given to patients receiving ganglion blocking compounds because a critical fall in blood pressure may occur. Usually, severe abdominal symptoms appear before there is such a fall in the blood pressure.
Myotonine Chloride Contraindications
Hypersensitivity to bethanechol chloride tablets, hyperthyroidism, peptic ulcer, latent or active bronchial asthma, pronounced bradycardia or hypotension, vasomotor instability, coronary artery disease, epilepsy, and parkinsonism.
Bethanechol chloride should not be employed when the strength or integrity of the gastrointestinal or bladder wall is in question, or in the presence of mechanical obstruction; when increased muscular activity of the gastrointestinal tract or urinary bladder might prove harmful, as following recent urinary bladder surgery, gastrointestinal resection and anastomosis, or when there is possible gastrointestinal obstruction; in bladder neck obstruction, spastic gastrointestinal disturbances, acute inflammatory lesions of the gastrointestinal tract, or peritonitis; or in marked vagotonia.
Additional information about Myotonine Chloride
Myotonine Chloride Indication: For the treatment of acute postoperative and postpartum nonobstructive (functional) urinary retention and for neurogenic atony of the urinary bladder with retention.
Mechanism Of Action: Myotonine Chloride acts by selectively stimulating muscarinic receptors in the parasympathetic nervous system, inducing no affect on nicotinic receptors.
Drug Interactions: Not Available
Food Interactions: Take on empty stomach: 1 hour before or 2 hours after meals to avoid nausea.
Generic Name: Bethanechol
Synonyms: Amidopropyldimethylbetaine; Beta-Methyl Carbachol Chloride; Besacholine; Bethaine Choline Chloride; Bethanechol Chloride; BTC; Carbamylmethylcholine Chloride
Drug Category: Parasympathomimetics
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Myotonine Chloride: Tablet Oral
Chemical IUPAC Name: 2-carbamoyloxypropyl-trimethylazanium
Chemical Formula: C7H17N2O2+
Bethanechol on Wikipedia: https://en.wikipedia.org/wiki/Bethanechol
Organisms Affected: Humans and other mammals