NP-27 Powder - General Information
NP-27 Powder is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin (Schering-Plough Corporation) and Odor Eaters (Combe Incorporated). Other brands are Absorbine, Aftate, Desenex, Genaspor, NP 27, and Ting.
Pharmacology of NP-27 Powder
NP-27 Powder is a synthetic over-the-counter anti-fungal agent.
Additional information about NP-27 Powder
NP-27 Powder Indication: NP-27 Powder topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. NP-27 Powder is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot.
Mechanism Of Action: Topical - Fungicidal; exact mechanism unknown; however, it has been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Tolnaftate
Synonyms: Not Available
Drug Category: Antifungal Agents
Drug Type: Small Molecule; Approved
Absorption: Not Available
Toxicity (Overdose): Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of NP-27 Powder: Liquid Topical
Chemical IUPAC Name: O-naphthalen-2-yl [methyl-(3-methylphenyl)amino]methanethioate
Chemical Formula: C19H17NOS
Tolnaftate on Wikipedia: https://en.wikipedia.org/wiki/Tolnaftate
Organisms Affected: Yeast and other fungi