Naganil - General Information

A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Naganil is manufactured by Bayer in Germany as Germanin®.


Pharmacology of Naganil

Not Available


Additional information about Naganil

Naganil Indication: For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
Mechanism Of Action: The mechanism is unknown, but the trypanocidal activity may be due to the inhibition of enzymes involved with the oxidation of reduced nicotinamide-adenine dinucleotide (NADH), which functions as a co-enzyme in many cellular reactions, such as respiration and glycolysis, in the trypanosome parasite. Naganil's action in the treatment of onchocerciasis is macrofilaricidal and partially microfilaricidal.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Suramin
Synonyms: Bayer 205; SVR; Sodium suramin; Suramin sodium; Suramine; Suramine sodium
Drug Category: Antinematodal Agents; Antineoplastic Agents; Trypanocidal Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Suramin: Germanin; Antrypol; Fourneau; Farma; Belganyl; Moranyl; Naganil; Naganin; Naganine; Naganol; Naphuride;
Absorption: Poorly absorbed from the gastrointestinal tract.
Toxicity (Overdose): Not Available
Protein Binding: Approximately 99.7%
Biotransformation: Little or no metabolism
Half Life: Approximately 36 to 60 days
Dosage Forms of Naganil: Injection, powder, for solution Intravenous
Chemical IUPAC Name: 8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonic acid
Chemical Formula: C51H40N6O23S6
Suramin on Wikipedia:
Organisms Affected: Yeast, Molds, Trypanosomes