Narcotan - General Information
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. nitrous oxide is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
Pharmacology of Narcotan
Narcotan is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It reduces the blood pressure and frequently decreases the pulse rate and depresses respiration. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Narcotan for patients
When appropriate, as in some cases where discharge is anticipated soon after general anesthesia, patients should be cautioned not to drive automobiles, operate hazardous machinery, or engage in hazardous sports for 24 hours or more (depending on the total dose of Halothane, condition of the patient, and consideration given to other drugs administered after anesthesia).
FLUOTHANE augments the action of non-depolarising muscle relaxants and the muscle relaxant effects of aminoglycosides.
FLUOTHANE may augment the hypotension caused by the ganglionic-blocking effect of tubocurarine.
Caution should be exercised during the administration of adrenaline to patients anaesthetised with FLUOTHANE as arrhythmias may be precipitated. For this reason the dose of adrenaline should be restricted and an antiarrhythmic agent administered as appropriate. Caution should also be applied for other sympathomimetics, and for aminophylline and theophylline and tricyclic antidepressants, which may also precipitate arrhythmias.
Fluothane is not recommended for obstetrical anesthesia except when uterine relaxation is required.
Additional information about Narcotan
Narcotan Indication: For the induction and maintenance of general anesthesia
Mechanism Of Action: Narcotan induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Narcotan also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Narcotan also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Halothane
Synonyms: Alotano [Dcit]; Bromchlortrifluoraethanum; Bromochlorotrifluoroethane; Cf3chclbr; Freon 123b1; Ftorotan [Russian]; Fluorothane; Fluorotane; Fluothane; Ftuorotan; Halotano [Inn-Spanish]; Halothan; Halothanum [Inn-Latin]; Narcotann Ne-Spofa [Russian]
Drug Category: Anesthetics; Anesthetics, Inhalation; General Anesthetics
Drug Type: Small Molecule; Approved
Other Brand Names containing Halothane: Anestan; Chalothane; Fluktan; Halan; Halotan; Halsan; Narcotan; Narcotane; Narkotan; Phthorothanum; Rhodialothan;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of Narcotan: Solution Respiratory (inhalation)
Liquid Respiratory (inhalation)
Chemical IUPAC Name: 2-bromo-2-chloro-1,1,1-trifluoroethane
Chemical Formula: C2HBrClF3
Halothane on Wikipedia: https://en.wikipedia.org/wiki/Halothane
Organisms Affected: Humans and other mammals