Nauzelin - General Information
A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms. [PubChem]
Pharmacology of Nauzelin
Nauzelin is a specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
Nauzelin for patients
Domperidone should not be used when patient have gastrointestinal hemorrhage, mechanical obstruction or perforation problems. Domperidone accumulation has been reported in patients with hepatic impairment.
Additional information about Nauzelin
Nauzelin Indication: For management of dyspepsia, heartburn, epigastric pain, nausea, and vomiting.
Mechanism Of Action: Gastrointestinal emptying (delayed) adjunct; peristaltic stimulant: The gastroprokinetic properties of domperidone are related to its peripheral dopamine receptor blocking properties. Nauzelin facilitates gastric emptying and decreases small bowel transit time by increasing esophageal and gastric peristalsis and by lowering esophageal sphincter pressure. Antiemetic: The antiemetic properties of domperidone are related to its dopamine receptor blocking activity at both the chemoreceptor trigger zone and at the gastric level.
Drug Interactions: Not Available
Food Interactions: Take 15 to 30 minutes before meals.
Generic Name: Domperidone
Synonyms: Not Available
Drug Category: Antiemetics; Dopamine Antagonists
Drug Type: Small Molecule; Approved
Toxicity (Overdose): Side effects include galactorrhea, gynecomastia, or menstrual irregularities.
Protein Binding: 91%-93%
Biotransformation: Not Available
Half Life: 7 hours
Dosage Forms of Nauzelin: Tablet Oral
Chemical IUPAC Name: 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one
Chemical Formula: C22H24ClN5O2
Domperidone on Wikipedia: https://en.wikipedia.org/wiki/Domperidone
Organisms Affected: Humans and other mammals