Navan - General Information

A thioxanthine used as an antipsychotic agent. Its effects are similar to the phenothiazine antipsychotics. [PubChem]


Pharmacology of Navan

Navan is an antipsychotic of the thioxanthene series. Navane possesses certain chemical and pharmacological similarities to the piperazine phenothiazines and differences from the aliphatic group of phenothiazines. Although widely used in the treatment of schizophrenia for several decades, thiothixene is seldom used today in favor of atypical antipsychotics such as risperidone.


Navan for patients

Given the likelihood that some patients exposed chronically to antipsychotics will develop tardive dyskinesia, it is advised that all patients in whom chronic use is contemplated be given, if possible, full information about this risk. The decision to inform patients and/or their guardians must obviously take into account the clinical circumstances and the competency of the patient to understand the information provided.


Navan Interactions


Navan Contraindications

Navane is contraindicated in patients with circulatory collapse, comatose states, central nervous system depression due to any cause, and blood dyscrasias. Navane is contraindicated in individuals who have shown hypersensitivity to the drug. It is not known whether there is a cross sensitivity between the thioxanthenes and the phenothiazine derivatives, but this possibility should be considered.


Additional information about Navan

Navan Indication: For the management of schizophrenia.
Mechanism Of Action: Not Available
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Thiothixene
Synonyms: Thiothixine; Tiotixene; Tiotixeno [inn-spanish]; Tiotixenum [inn-latin]; Cis-thiothixene; (e)-thiothixene
Drug Category: Antipsychotic Agents; Dopamine Antagonists
Drug Type: Small Molecule; Approved

Other Brand Names containing Thiothixene: Navan; Navaron; Orbinamon; Navane;
Absorption: Not Available
Toxicity (Overdose): Symptoms of overdose include central nervous system depression, coma, difficulty swallowing, dizziness, drowsiness, head tilted to the side, low blood pressure, muscle twitching, rigid muscles, salivation, tremors, walking disturbances, and weakness.
Protein Binding: Not Available
Biotransformation: Hepatic.
Half Life: 10-20 hours
Dosage Forms of Navan: Capsule Oral
Chemical IUPAC Name: (9Z)-N,N-dimethyl-9-[3-(4-methylpiperazin-1-yl)propylidene]thioxanthene-2-sulfonamide
Chemical Formula: C23H29N3O2S2
Thiothixene on Wikipedia:
Organisms Affected: Humans and other mammals