Nix - General Information
A pyrethroid insecticide commonly used in the treatment of lice infestations and scabies. It is a yellow to light orange-brown, low melt-ing solid or viscous liquid.
Pharmacology of Nix
Nix, a pyrethroid, is active against a broad range of pests including lice, ticks, fleas, mites, and other arthropods.
Additional information about Nix
Nix Indication: For the treatment of infestation with Sarcoptes scabiei (scabies).
Mechanism Of Action: Nix acts on the nerve cell membrane to disrupt the sodium channel current by which the polarization of the membrane is regulated. Delayed repolarization and paralysis of the pests are the consequences of this disturbance.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Permethrin
Synonyms: Not Available
Drug Category: Enzyme Inhibitors; Insecticides
Drug Type: Small Molecule; Approved; Investigational
Other Brand Names containing Permethrin: PerFoam; Acticin Cream; Elimite; Elimite Cream; Nix; Nix Cream Rinse;
Absorption: Poorly absorbed through the skin.
Toxicity (Overdose): Oral, rat LD50: 430 - 4000 mg/kg; skin, rabbit LD50: 2000 mg/kg.
Protein Binding: Not Available
Biotransformation: Rapidly metabolized by ester hydrolysis to inactive metabolites which are excreted primarily in the urine.
Half Life: Not Available
Dosage Forms of Nix: Cream Topical
Chemical IUPAC Name: [3-(phenoxy)phenyl]methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate
Chemical Formula: C21H20Cl2O3
Permethrin on Wikipedia: https://en.wikipedia.org/wiki/Permethrin
Organisms Affected: Scabies (Sarcoptes scabei) and other insects