Nometic - General Information

Nometic is an antiemetic agent used in the treatment of vomiting and vertigo. Nometic overdose may result in serious toxicity in children.


Pharmacology of Nometic

Nometic is used for control of nausea and vomiting. It has an antivertigo effect on the vestibular apparatus, inhibiting the chemoreceptor trigger zone to control nausea and vomiting, thus preventing motion sickness.


Nometic for patients


Nometic Interactions

CNS depression–producing medications - concurrent use may potentiate the effects of either these medications or diphenidol; anticholinergics or other medications with anticholinergic activity - anticholinergic effects may be potentiated when these medications are used concurrently with diphenidol; apomorphine - prior ingestion of diphenidol may decrease the emetic response to apomorphine in the treatment of poisoning.


Nometic Contraindications

Anuria - renal shutdown may increase risk of systemic accumulation of diphenidol.


Additional information about Nometic

Nometic Indication: For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear. Also for the control of nausea and vomiting associated with postoperative states, malignant neoplasms, labyrinthine disturbances, antineoplastic agent therapy, radiation sickness, and infectious diseases.
Mechanism Of Action: The mechanism by which diphenidol exerts its antiemetic and antivertigo effects is not precisely known. It is thought to diminish vestibular stimulation and depress labyrinthine function. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Nometic has no significant sedative, tranquilizing, or antihistaminic action. It has a weak peripheral anticholinergic effect.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Diphenidol
Synonyms: Difenidol HCl; Difenidol; Difenidol hydrochloride; Difenidolo [DCIT]; Difenidolum [INN-Latin]; Diphenidol HCl; Diphenidol hydrochloride
Drug Category: Antiemetics; Antivertigo Agents
Drug Type: Small Molecule; Approved

Other Brand Names containing Diphenidol: Ansmin; Avomol; Celmidol; Cephadol; Cerrosa; Maniol; Nometic; Satanolon; Verterge; Vontrol; Yesdol;
Absorption: Well absorbed from gastrointestinal tract following oral administration.
Toxicity (Overdose): Symptoms of overdose include drowsiness (severe); shortness of breath or troubled breathing; unusual tiredness or weakness (severe).
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 4 hours
Dosage Forms of Nometic: Tablet Oral
Chemical IUPAC Name: 1,1-di(phenyl)-4-piperidin-1-ylbutan-1-ol
Chemical Formula: C21H27NO
Diphenidol on Wikipedia: Not Available
Organisms Affected: Humans and other mammals