Norval - General Information

A tetracyclic compound with antidepressant effects. Norval was previously available internationally, however in most markets it has been phased out in favor of Mirtazapine.


Pharmacology of Norval

Norval is a tetracyclic antidepressant that has antihistaminic and hypnosedative, but almost no anticholinergic, effect. It is a weak inhibitor of norepinephrine reuptake and strongly stimulates the release of norepinephrine. Interactions with serotonin receptors in the central nervous system have also been found. Its effect is usually noticeable after one to three weeks. Norval may cause drowsiness and hematological problems.


Additional information about Norval

Norval Indication: For the treatment of depression.
Mechanism Of Action: Norval's mechanism of therapeutic action is not well understood, although it apparently blocks alpha-adrenergic, histamine H1, and some types of serotonin receptors.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Mianserin
Synonyms: Mianseryna [polish]; Mianserinum [inn-latin]; Mianserine [inn-french]; Mianserina [inn-spanish]; Mianserine
Drug Category: Adrenergic alpha-Antagonists; Histamine H1 Antagonists; Serotonin Antagonists; Antidepressive Agents, Second-Generation
Drug Type: Small Molecule; Approved

Other Brand Names containing Mianserin: Bolvidon; Norval; Tolvan;
Absorption: Absorbed following oral administration.
Toxicity (Overdose): Oral rat LD50: 780mg/kg
Protein Binding: 90%
Biotransformation: Hepatic.
Half Life: 10-17 hours
Dosage Forms of Norval: Not Available
Chemical IUPAC Name: Not Available
Chemical Formula: C18H20N2
Mianserin on Wikipedia:
Organisms Affected: Humans and other mammals