Oby-Trim - General Information
A central nervous system stimulant and sympathomimetic with actions and uses similar to those of dextroamphetamine. It has been used most frequently in the treatment of obesity. [PubChem]
Pharmacology of Oby-Trim
Oby-Trim is indicated in the management of exogenous obesity as a short term (a few weeks) adjunct in a regimen of weight reduction based on caloric restriction. Oby-Trim hydrochloride is a sympathomimetic amine with pharmacologic activity similar to the prototype drugs of this class used in obesity, the amphetamines. Actions include central nervous system stimulation and elevation of blood pressure. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class in which these phenomena have been looked for.
Oby-Trim for patients
Concomitant use of alcohol with phentermine hydrochloride may result in an adverse drug interaction.
Advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyperthyroidism, known hypersensitivity, or idiosyncrasy to the sympathomimetic amines, glaucoma.
Patients with a history of drug abuse.
During or within 14 days following the administration of monoamine oxidase inhibitors (hypertensive crises may result).
Additional information about Oby-Trim
Oby-Trim Indication: For the treatment and management of obesity.
Mechanism Of Action: Oby-Trim is an amphetamine that stimulates neurons to release or maintain high levels of a particular group of neurotransmitters known as catecholamines; these include dopamine and norepinephrine. High levels of these catecholamines tend to suppress hunger signals and appetite. Oby-Trim (through catecholamine elevation) may also indirectly affect leptin levels in the brain. It is theorized that phentermine can raise levels of leptin which signal satiety. It is also theorized that increased levels of the catecholamines are partially responsible for halting another chemical messenger known as neuropeptide Y. This peptide initiates eating, decreases energy expenditure, and increases fat storage.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Phentermine
Synonyms: Phentermine Hcl; Phentermine Hydrochloride; (alpha,alpha)-Dimethylphenethylamine
Drug Category: Adrenergic Agents; Appetite Depressants; Central Nervous System Agents; Anorexigenic Agents; Stimulants
Drug Type: Small Molecule; Illicit; Approved
Absorption: Phentermine is rapidly absorbed after oral ingestion.
Toxicity (Overdose): LD50 is adult monkeys is 15 to 20 mg/kg. Symptoms of overdose include delirium, mania, self-injury, marked hypertension, tachycardia, arrhythmia, hyperpyrexia, convulsion, coma, and circulatory collapse.
Protein Binding: Approximately 96.3%
Half Life: 16 to 31 hours
Dosage Forms of Oby-Trim: Capsule Oral
Chemical IUPAC Name: 2-methyl-1-phenylpropan-2-amine
Chemical Formula: C10H15N
Phentermine on Wikipedia: https://en.wikipedia.org/wiki/Phentermine
Organisms Affected: Humans and other mammals