One Alpha

One Alpha - General Information

One Alpha is an active metabolite of Vitamin D, which performs important functions in regulation of the calcium balance and the bone metabolism. One Alpha is Vitamin D-hormone analog which is activated by the enzyme 25-hydroxylase in the liver for systemic and in osteoblasts for local D-hormone actions. It possesses a unique pattern of pleiotropic effects on, e.g. gut, bone, pararthyroids, muscle and brain. One Alpha is superior to plain vitamin D (cholecalciferol) because the final kidney activation of the latter is regulated by a negative feedback mechanism. (PMID:17438884,17668216)


Pharmacology of One Alpha

Not Available


Additional information about One Alpha

One Alpha Indication: Not Available
Mechanism Of Action: Not Available
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Alfacalcidol
Synonyms: 1alpha-hydroxycholecalciferol; 1alpha-hydroxyvitamin D3; 1-hydroxycholecalciferol
Drug Category: Bone Density Conservation Agents
Drug Type: Small Molecule; Nutraceutical; Approved

Other Brand Names containing Alfacalcidol: One Alpha; Alsiodol;
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: Not Available
Dosage Forms of One Alpha: Capsule Oral
Solution / drops Oral
Liquid Intravenous
Solution / drops Oral
Liquid Intravenous
Capsule Oral
Chemical IUPAC Name: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
Chemical Formula: C27H44O2
Alfacalcidol on Wikipedia: Not Available
Organisms Affected: Humans and other mammals