Ontak (Seragen Inc)

Ontak (Seragen Inc) - General Information

A recombinant DNA-derived cytotoxic protein composed of the amino acid sequences for diphtheria toxin fragments A and B (Met 1-Thr 387)-His followed by the sequences for interleukin-2 (IL-2; Ala 1-Thr 133). It is produced in an E. coli expression system.


Pharmacology of Ontak (Seragen Inc)

Ontak (Seragen Inc) (Ontak) directs the cytocidal action of diphtheria toxin to cells which express the IL-2 receptor. The human IL-2 receptor exists in three forms, low (CD25), intermediate (CD122/CD132) and high (CD25/CD122/CD132) affinity. Malignant cells expressing one or more of the subunits of the IL-2 receptor are found in certain leukemias and lymphomas including cutaneous T-cell lymphoma (CTCL). Ontak interacts with the high affinity IL-2 receptor on the cell surface and inhibits cellular protein synthesis, resulting in cell death within hours.


Ontak (Seragen Inc) for patients


Ontak (Seragen Inc) Interactions

No clinical drug interaction studies have been conducted. However, in a single in vivo rodent study denileukin diftitox had no effect on P450 levels.


Ontak (Seragen Inc) Contraindications

ONTAK is contraindicated for use in patients with a known hypersensitivity to denileukin diftitox or any of its components: diphtheria toxin, interleukin-2, or excipients.


Additional information about Ontak (Seragen Inc)

Ontak (Seragen Inc) Indication: For treatment of cutaneous T-cell lymphoma
Mechanism Of Action: Ontak binds to the high-affinity IL-2 receptor complex. The IL-2 receptor (Tac) subunit is expressed on activated but not resting lymphocytes. The diphtheria toxin associated with Ontak then selectively kills the IL-2 bearing cells.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Denileukin diftitox
Synonyms: DT; Diphtheria toxin precursor; NAD(+--diphthamide ADP- ribosyltransferase)
Drug Category: Antineoplastic Agents
Drug Type: Biotech; Approved; Investigational

Other Brand Names containing Denileukin diftitox: Ontak (Seragen Inc);
Absorption: Not Available
Toxicity (Overdose): Not Available
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 70-80 min
Dosage Forms of Ontak (Seragen Inc): Solution Intravenous
Chemical IUPAC Name: Diptheria toxin-Interleukin-2 fusion protein
Chemical Formula: C2560H4042N678O799S17
Denileukin diftitox on Wikipedia:
Organisms Affected: Humans and other mammals