Organidin NR - General Information
An expectorant that also has some muscle relaxing action. It is used in many cough preparations. [PubChem]
Pharmacology of Organidin NR
Organidin NR is an expectorant which increases the output of phlegm (sputum) and bronchial secretions by reducing adhesiveness and surface tension. The increased flow of less viscous secretions promotes ciliary action and changes a dry, unproductive cough to one that is more productive and less frequent. By reducing the viscosity and adhesiveness of secretions, guaifenesin increases the efficacy of the mucociliary mechanism in removing accumulated secretions from the upper and lower airway.
Organidin NR for patients
TUSSI-ORGANIDIN® NR* (* Newly Reformulated): Patients should be warned about engaging in activities requiring mental alertness, such as driving a car or operating dangerous machinery. Take as prescribed; do not exceed prescribed dose or frequency. Do not crush or chew extended release tablet. Maintain adequate hydration (2-3l L/d of fluids) unless instructed to restrict fluid intake.
TUSSI-ORGANIDIN® DM NR* (* Newly Reformulated): Patients should be warned not to use this product if they are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric or emotional conditions, or Parkinson's disease), or for 2 weeks after stopping the M.O. drug. If patients are uncertain whether a prescription drug contains an MAOI, they should be instructed to consult a health professional before taking such a product.
Organidin NR Interactions
Serious toxicity may result if dextromethorphan is coadministered with monoamine oxidase inhibitors (MAOIs). The use of dextromethorphan hydrobromide may result in additive CNS depressant effects when coadministered with alcohol, antihistamines, psychotropics or other drugs that produce CNS depression.
Organidin NR Contraindications
Hypersensitivity to any of the ingredients. The use of dextromethorphan-containing products are contraindicated in patients receiving monoamine oxidase inhibitors (MAOIs).
Additional information about Organidin NR
Organidin NR Indication: Used to assist the expectoration of phlegm from the airways in acute respiratory tract infections.
Mechanism Of Action: Organidin NR may act as an irritant to gastric vagal receptors, and recruit efferent parasympathetic reflexes that cause glandular exocytosis of a less viscous mucus mixture. Cough may be provoked. This combination may flush tenacious, congealed mucopurulent material from obstructed small airways and lead to a temporary improvement in dyspnea or the work of breathing.
Drug Interactions: Not Available
Food Interactions: Take with a full glass of water.
Take without regard to meals.
Generic Name: Guaifenesin
Synonyms: o-Methoxyphenyl glyceryl ether; Methoxypropanediol; Metfenossidiolo; Methphenoxydiol; Metossipropandiolo; Guiaphenesin; Glyceryl guiacolate; Glyceryl guaicolate; Glyceryl guaiacyl ether; Glyceryl guaiacolate ether; Glyceryl guaiacolate; Glyceryl guaiacol ether; Glyceryl guaiacol; Glycerol guaiacolate; Glycero-guaiacol ether; Glycerin monoguaiacol ether; Glycerin guaiacolate
Drug Category: Expectorants
Drug Type: Small Molecule; Approved
Absorption: Rapidly absorbed from the GI tract
Toxicity (Overdose): LD50 1510 mg/kg (rat, oral)
Protein Binding: Not Available
Biotransformation: Rapidly hydrolyzed (60% within seven hours) and then excreted in the urine, with beta-(2-methoxyphenoxy)-lactic acid as its major urinary metabolite.
Half Life: 1 hour
Dosage Forms of Organidin NR: Liquid Oral
Chemical IUPAC Name: 3-(2-methoxyphenoxy)propane-1,2-diol
Chemical Formula: C10H14O4
Guaifenesin on Wikipedia: https://en.wikipedia.org/wiki/Guaifenesin
Organisms Affected: Humans and other mammals