Paginol - General Information
Paginol is a medication in the class of beta blockers, used in the treatment of high blood pressure. [Wikipedia]
Pharmacology of Paginol
Paginol is a non-selective beta blocker. Beta-blockers work by affecting the response to some nerve impulses in certain parts of the body. As a result, they decrease the heart's need for blood and oxygen by reducing its workload. They also help the heart to beat more regularly.
Additional information about Paginol
Paginol Indication: Used in the treatment of high blood pressure.
Mechanism Of Action: Paginol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension.
Drug Interactions: Not Available
Food Interactions: Not Available
Generic Name: Penbutolol
Synonyms: Penbutolol sulfate
Drug Category: Adrenergic beta-Antagonists; Antihypertensive Agents
Drug Type: Small Molecule; Approved
Absorption: Oral bioavailability is 90%.
Toxicity (Overdose): Symptoms of overdose include drowsiness, vertigo, headache, and atriventricular block.
Protein Binding: 80-98% bound to plasma proteins.
Biotransformation: Metabolized in the liver by hydroxylation and glucuroconjugation forming a glucuronide metabolite and a semi-active 4-hydroxy metabolite.
Half Life: Phase 1: 2.5 hours; phase 2: 24 hours
Dosage Forms of Paginol: Tablet Oral
Chemical IUPAC Name: (2S)-1-(tert-butylamino)-3-(2-cyclopentylphenoxy)propan-2-ol
Chemical Formula: C18H29NO2
Penbutolol on Wikipedia: https://en.wikipedia.org/wiki/Penbutolol
Organisms Affected: Humans and other mammals